Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2024065..2024578 Replicon chromosome
Accession NZ_LT906460
Organism Staphylococcus simiae strain NCTC13838

Toxin (Protein)


Gene name TsdT Uniprot ID G5JKY0
Locus tag CKV88_RS09430 Protein ID WP_002464831.1
Coordinates 2024065..2024274 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID G5JKX9
Locus tag CKV88_RS09435 Protein ID WP_002464830.1
Coordinates 2024285..2024578 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV88_RS09410 2019585..2020943 - 1359 WP_002464834.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
CKV88_RS09415 2020958..2022028 - 1071 WP_002464833.1 D-alanine--D-alanine ligase -
CKV88_RS09420 2022345..2023544 + 1200 WP_002464832.1 rod shape-determining protein RodA -
CKV88_RS09425 2023805..2023942 - 138 WP_000828354.1 hypothetical protein -
CKV88_RS09430 2024065..2024274 - 210 WP_002464831.1 heavy-metal-associated domain-containing protein Toxin
CKV88_RS09435 2024285..2024578 - 294 WP_002464830.1 copper-sensing transcriptional repressor CsoR Antitoxin
CKV88_RS09440 2024759..2026243 + 1485 WP_002464829.1 cardiolipin synthase -
CKV88_RS09445 2026268..2026918 + 651 WP_002464828.1 HD domain-containing protein -
CKV88_RS09450 2027079..2027945 - 867 WP_002464827.1 membrane protein insertase YidC -
CKV88_RS09455 2028031..2028675 - 645 WP_002464826.1 thiamine phosphate synthase -
CKV88_RS09460 2028672..2029466 - 795 WP_002464825.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(18-67)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7540.45 Da        Isoelectric Point: 4.1591

>T293720 WP_002464831.1 NZ_LT906460:c2024274-2024065 [Staphylococcus simiae]
MINNSVIHTAGIETEEQAQHVSAILKAMIGVKSANVNIVDGSVEVEYETPSNLDSIEKEIYDAGYKVIY

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11160.73 Da        Isoelectric Point: 5.6326

>AT293720 WP_002464830.1 NZ_LT906460:c2024578-2024285 [Staphylococcus simiae]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATVLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G5JKY0

Antitoxin

Source ID Structure
AlphaFold DB G5JKX9

References