Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2012017..2012549 Replicon chromosome
Accession NZ_LT906460
Organism Staphylococcus simiae strain NCTC13838

Toxin (Protein)


Gene name mazF Uniprot ID G5JLV8
Locus tag CKV88_RS09370 Protein ID WP_002465156.1
Coordinates 2012017..2012382 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G5JLV7
Locus tag CKV88_RS09375 Protein ID WP_002465155.1
Coordinates 2012379..2012549 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV88_RS09350 2008225..2008995 - 771 WP_002464557.1 RNA polymerase sigma factor SigB -
CKV88_RS09355 2008970..2009449 - 480 WP_002464556.1 anti-sigma B factor RsbW -
CKV88_RS09360 2009451..2009777 - 327 WP_002464555.1 anti-sigma factor antagonist -
CKV88_RS09365 2009895..2010896 - 1002 WP_002464554.1 PP2C family protein-serine/threonine phosphatase -
CKV88_RS09370 2012017..2012382 - 366 WP_002465156.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CKV88_RS09375 2012379..2012549 - 171 WP_002465155.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
CKV88_RS09380 2012634..2013782 - 1149 WP_002465154.1 alanine racemase -
CKV88_RS09385 2013846..2014202 - 357 WP_002465153.1 holo-ACP synthase -
CKV88_RS09390 2014250..2014723 - 474 WP_002465152.1 PH domain-containing protein -
CKV88_RS09395 2014710..2016266 - 1557 WP_002465151.1 PH domain-containing protein -
CKV88_RS09400 2016259..2016738 - 480 WP_002465150.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13514.85 Da        Isoelectric Point: 10.2631

>T293719 WP_002465156.1 NZ_LT906460:c2012382-2012017 [Staphylococcus simiae]
MIKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALIISLGLTTLSQHKLS

Download         Length: 366 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6223.72 Da        Isoelectric Point: 3.8305

>AT293719 WP_002465155.1 NZ_LT906460:c2012549-2012379 [Staphylococcus simiae]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNESYLSSNSSNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G5JLV8

Antitoxin

Source ID Structure
AlphaFold DB G5JLV7

References