Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1850416..1851192 Replicon chromosome
Accession NZ_LT906460
Organism Staphylococcus simiae strain NCTC13838

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag CKV88_RS08545 Protein ID WP_002461710.1
Coordinates 1850416..1850571 (-) Length 52 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID G5JFE6
Locus tag CKV88_RS08550 Protein ID WP_002461709.1
Coordinates 1850593..1851192 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV88_RS08525 1845583..1846704 - 1122 WP_002461714.1 GAF domain-containing sensor histidine kinase -
CKV88_RS08530 1846863..1847684 + 822 WP_095092771.1 RluA family pseudouridine synthase -
CKV88_RS08535 1848296..1849681 - 1386 WP_002461712.1 class II fumarate hydratase -
CKV88_RS08540 1849863..1850264 - 402 WP_002461711.1 hypothetical protein -
CKV88_RS08545 1850416..1850571 - 156 WP_002461710.1 hypothetical protein Toxin
CKV88_RS08550 1850593..1851192 - 600 WP_002461709.1 hypothetical protein Antitoxin
CKV88_RS08555 1851486..1851956 - 471 WP_002461708.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
CKV88_RS08560 1851958..1853088 - 1131 WP_002461707.1 tRNA epoxyqueuosine(34) reductase QueG -
CKV88_RS08565 1853231..1853953 - 723 Protein_1664 amino acid ABC transporter ATP-binding protein -
CKV88_RS08570 1853946..1855403 - 1458 WP_002461705.1 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 6085.35 Da        Isoelectric Point: 4.0406

>T293718 WP_002461710.1 NZ_LT906460:c1850571-1850416 [Staphylococcus simiae]
MFNEKDAKSNYHEDENAMVNDFDDLKELGKEMEQISEENDQEKHNQSHDNN

Download         Length: 156 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22446.33 Da        Isoelectric Point: 4.6276

>AT293718 WP_002461709.1 NZ_LT906460:c1851192-1850593 [Staphylococcus simiae]
MAMNFKVFDNSQLVADYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVDHYAVDFSQINILDYDNNQSYFEALGV
PESQIYAIGFEKDAIEFISDKIKTKENKGKLTLQVLSISEQGNLDVSVRQGLMEAREIILVITGSNKRGLVEKLYQENGK
TSYEPADLKAHRMVNVILDKEAAEGLPEDVKTYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G5JFE6

References