Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1560978..1562622 Replicon chromosome
Accession NZ_LT906458
Organism Pasteurella multocida strain NCTC10322

Toxin (Protein)


Gene name hipA Uniprot ID V4NI19
Locus tag CKV69_RS07180 Protein ID WP_005752891.1
Coordinates 1561315..1562622 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID V4NAB0
Locus tag CKV69_RS07175 Protein ID WP_005752888.1
Coordinates 1560978..1561313 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV69_RS07150 1557056..1557715 + 660 WP_005724855.1 bifunctional tRNA pseudouridine(32) synthase/23S rRNA pseudouridine(746) synthase RluA -
CKV69_RS07155 1557779..1558348 + 570 WP_014326417.1 Der GTPase-activating protein YihI -
CKV69_RS07160 1558354..1558782 + 429 WP_005719208.1 DUF2489 domain-containing protein -
CKV69_RS07165 1558806..1560173 + 1368 WP_016504414.1 oxygen-independent coproporphyrinogen III oxidase -
CKV69_RS07170 1560214..1560882 + 669 WP_014326419.1 NAD(P)H-dependent oxidoreductase -
CKV69_RS07175 1560978..1561313 - 336 WP_005752888.1 helix-turn-helix domain-containing protein Antitoxin
CKV69_RS07180 1561315..1562622 - 1308 WP_005752891.1 HipA domain-containing protein Toxin
CKV69_RS07185 1562841..1563977 + 1137 WP_075266242.1 anhydro-N-acetylmuramic acid kinase -
CKV69_RS07190 1564043..1566625 - 2583 WP_014326421.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-375)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 50526.31 Da        Isoelectric Point: 4.9118

>T293714 WP_005752891.1 NZ_LT906458:c1562622-1561315 [Pasteurella multocida]
MEKLTLQIYLEQAWCDLAFLYFDSETYQLCNFEYLTDYVVQHYGKTGEHAVSLNYPVNVFIDDTTSLWSWLSDIAPAGAS
RRYWLEALDIKQESEEKQQFLLLKHAAISPIGNLRIKDAVPEQVEVRLFDLDKAKDRQSDFLEYVNQSGAMVGGATGAGG
EAPKLLLKRRENQVWIDNQQQGQDQDVSYLVKYPRGNYSPIDCDILRAEYHYYQELAQLGFDTIDTTRMRLEEGKRYPSL
WLPRFDIVQREGKTHRLAFESVYSLLQKQGGVLDHETTLRQLIERISTARLQFAQTDFVIEWVKRDLLNIAFGNSDNHGR
NMAFLRDEQRIWLAPIYDFAPMRADPEGIIRTTTWQTKGEYPQEFAGEYHFERIAEVLADLVEPTLLMQELRRLAGSLVD
LKSRLVQRNLPQSILDFPAIGFDYLPEKLKKWGLI

Download         Length: 1308 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12520.60 Da        Isoelectric Point: 10.5259

>AT293714 WP_005752888.1 NZ_LT906458:c1561313-1560978 [Pasteurella multocida]
MQITRRNASTKGASVAEIDRKKVRNEIIQAMLMGELSQGEALRKLRIEMFGINQQHYIQLVKVSRQTLSNIENDKGNYSV
ETINKVFKPFGLELGLVPVSKALLKELFSTA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V4NI19

Antitoxin

Source ID Structure
AlphaFold DB V4NAB0

References