Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 631200..632662 Replicon chromosome
Accession NZ_LT906457
Organism Legionella spiritensis strain NCTC11990

Toxin (Protein)


Gene name rlegT Uniprot ID A0A0W0YYF7
Locus tag CKW05_RS02940 Protein ID WP_058484381.1
Coordinates 631200..632057 (-) Length 286 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A0W0YYC1
Locus tag CKW05_RS02945 Protein ID WP_058484380.1
Coordinates 632054..632662 (-) Length 203 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW05_RS02905 626306..626692 + 387 WP_058484387.1 hypothetical protein -
CKW05_RS02910 627062..627589 - 528 WP_058484386.1 cytochrome b -
CKW05_RS02915 627601..629010 - 1410 WP_058484385.1 hypothetical protein -
CKW05_RS02930 629512..630090 - 579 WP_058484383.1 hypothetical protein -
CKW05_RS02935 630734..631156 - 423 WP_058484382.1 acyl-CoA thioesterase -
CKW05_RS02940 631200..632057 - 858 WP_058484381.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
CKW05_RS02945 632054..632662 - 609 WP_058484380.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
CKW05_RS02950 632808..633067 - 260 Protein_551 DUF4102 domain-containing protein -
CKW05_RS02955 633061..634851 - 1791 WP_058484379.1 serine hydrolase -
CKW05_RS02960 634946..636559 - 1614 WP_058484378.1 HAMP domain-containing histidine kinase -
CKW05_RS02965 636556..637242 - 687 WP_058484377.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(35-261)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(11-89)


Sequences

Toxin        


Download         Length: 286 a.a.        Molecular weight: 32014.93 Da        Isoelectric Point: 4.9268

>T293712 WP_058484381.1 NZ_LT906457:c632057-631200 [Legionella spiritensis]
MMKDISASIRARLKNIAKEEQTDFNAVLTRYGLERLLYRIGQSEYANQYLLKGALLFNLWYDMPHRPTLDIDLLGFGNNE
LDYLTGVFKEICIISAADGIIFDEKSVSANTIKKEGGYTGARIELFAELSKARIKIQIDIGYGDVVTPGPIDLNYPVLIS
DLPPPKIRTYPIYTVIAEKLHAIALLGMANSRLKDYLDLYVLLKNEELDEETVIDAIISTFTQRGMTIPKNLPIGLTSEY
SQDGSRQAMWNSFLNKNEVELKPLPEAVSSIGDYIQPILVKASTR

Download         Length: 858 bp

Antitoxin


Download         Length: 203 a.a.        Molecular weight: 23105.03 Da        Isoelectric Point: 9.2416

>AT293712 WP_058484380.1 NZ_LT906457:c632662-632054 [Legionella spiritensis]
MNAEKNYKQTVLNMVREKGIIKISELTKKGITRATVSRLVSENKLEKIATGLYCLPETEFSEKESLVILASRVPQAVFCL
LTALQIHELTTQLPRKVWIAMPRGSHTPKIDYPPVKMIQYSKEVYEEGIETIESDNIKLRVYNSAKTIADCFKHRTTIGI
DVAIEALKEAYSKNKVSMDELWHYAKICRVANIMRPYLEAIQ

Download         Length: 609 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0YYF7

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0YYC1

References