Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipA-higA/HipA-HTH_31
Location 81368..82934 Replicon chromosome
Accession NZ_LT906457
Organism Legionella spiritensis strain NCTC11990

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CKW05_RS00415 Protein ID WP_095140518.1
Coordinates 81639..82934 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKW05_RS00410 Protein ID WP_095140675.1
Coordinates 81368..81544 (-) Length 59 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW05_RS00390 77648..78217 + 570 WP_133141164.1 hypothetical protein -
CKW05_RS00395 78578..80620 + 2043 WP_058484807.1 diguanylate cyclase -
CKW05_RS00400 80839..81029 - 191 Protein_76 hypothetical protein -
CKW05_RS00410 81368..81544 - 177 WP_095140675.1 helix-turn-helix domain-containing protein Antitoxin
CKW05_RS00415 81639..82934 - 1296 WP_095140518.1 HipA domain-containing protein Toxin
CKW05_RS00420 82921..83202 - 282 WP_058484723.1 helix-turn-helix domain-containing protein -
CKW05_RS00425 83326..84531 - 1206 WP_058484722.1 site-specific integrase -
CKW05_RS00430 85074..85586 + 513 WP_058484721.1 hypothetical protein -
CKW05_RS00435 85776..87920 - 2145 WP_058484720.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 79896..326704 246808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(1-50)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 49058.04 Da        Isoelectric Point: 6.4000

>T293711 WP_095140518.1 NZ_LT906457:c82934-81639 [Legionella spiritensis]
MIGSEHVLDVYLGDNIIAELSLVNDQLHWHYRPDWQQNGYPVSPHLPLDREIPPLNVTRFLRNLLPEGNALEELINTFHL
SKGNTFGLVRALGLDTPGSLVFRSPTQSSPIKTSFRPVLDKELEQRLDSRDEFSLIIWDGKPRLSVAGVQDKINVVLNEE
NQLGFGEGNLCSTHILKFEKQKLAHLVLNEYVTMRLARLCGLNVANAKLLCYGKNPALLVERFDRHFISLTEVKRRHMID
GCQALNVPPDYKYERNFGSGRDVAHIRDGVSLEKLFEFANQCENPALAKQRMLDWVLFNTLIFNCDAHGKNISFFVGSKG
LSLTPFYDLVNIKMYPEFEHDLAMALGDEFDENNVNAYQLADFADTCQLPRSFVTNRLKYLGKKLSASVGECHSAGINDD
ERAYLHHYKKMIQERCNHLLKEADGIVSMEL

Download         Length: 1296 bp

Antitoxin


Download         Length: 59 a.a.        Molecular weight: 6476.39 Da        Isoelectric Point: 10.5679

>AT293711 WP_095140675.1 NZ_LT906457:c81544-81368 [Legionella spiritensis]
MRQKAGLTQEELAQRMGTQKGNISRLEKGSSNPSWKTLEKYAHACGFDISMAFKRTAS

Download         Length: 177 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References