Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipA-higA/HipA-HTH_31
Location 81368..82934 Replicon chromosome
Accession NZ_LT906457
Organism Legionella spiritensis strain NCTC11990

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CKW05_RS00415 Protein ID WP_095140518.1
Coordinates 81639..82934 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag CKW05_RS00410 Protein ID WP_095140675.1
Coordinates 81368..81544 (-) Length 59 a.a.

Genomic Context

CKW05_RS00390CKW05_RS00395CKW05_RS00430CKW05_RS00400CKW05_RS00410CKW05_RS00415CKW05_RS00420CKW05_RS00425CKW05_RS00435
Location: 77648..78217 (570 bp)
Type: Others
Protein ID: WP_133141164.1
Location: 78578..80620 (2043 bp)
Type: Others
Protein ID: WP_058484807.1
Location: 85074..85586 (513 bp)
Type: Others
Protein ID: WP_058484721.1
Location: 80839..81029 (191 bp)
Type: Others
Protein ID: Protein_76
Location: 81368..81544 (177 bp)
Type: Antitoxin
Protein ID: WP_095140675.1
Location: 81639..82934 (1296 bp)
Type: Toxin
Protein ID: WP_095140518.1
Location: 82921..83202 (282 bp)
Type: Others
Protein ID: WP_058484723.1
Location: 83326..84531 (1206 bp)
Type: Others
Protein ID: WP_058484722.1
Location: 85776..87920 (2145 bp)
Type: Others
Protein ID: WP_058484720.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CKW05_RS0039077648..78217+570WP_133141164.1hypothetical protein-
CKW05_RS0039578578..80620+2043WP_058484807.1diguanylate cyclase-
CKW05_RS0040080839..81029-191Protein_76hypothetical protein-
CKW05_RS0041081368..81544-177WP_095140675.1helix-turn-helix domain-containing proteinAntitoxin
CKW05_RS0041581639..82934-1296WP_095140518.1HipA domain-containing proteinToxin
CKW05_RS0042082921..83202-282WP_058484723.1helix-turn-helix domain-containing protein-
CKW05_RS0042583326..84531-1206WP_058484722.1site-specific integrase-
CKW05_RS0043085074..85586+513WP_058484721.1hypothetical protein-
CKW05_RS0043585776..87920-2145WP_058484720.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--79896..326704246808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(1-50)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 49058.04 Da        Isoelectric Point: 6.4000

>T293711 WP_095140518.1 NZ_LT906457:c82934-81639 [Legionella spiritensis]
MIGSEHVLDVYLGDNIIAELSLVNDQLHWHYRPDWQQNGYPVSPHLPLDREIPPLNVTRFLRNLLPEGNALEELINTFHL
SKGNTFGLVRALGLDTPGSLVFRSPTQSSPIKTSFRPVLDKELEQRLDSRDEFSLIIWDGKPRLSVAGVQDKINVVLNEE
NQLGFGEGNLCSTHILKFEKQKLAHLVLNEYVTMRLARLCGLNVANAKLLCYGKNPALLVERFDRHFISLTEVKRRHMID
GCQALNVPPDYKYERNFGSGRDVAHIRDGVSLEKLFEFANQCENPALAKQRMLDWVLFNTLIFNCDAHGKNISFFVGSKG
LSLTPFYDLVNIKMYPEFEHDLAMALGDEFDENNVNAYQLADFADTCQLPRSFVTNRLKYLGKKLSASVGECHSAGINDD
ERAYLHHYKKMIQERCNHLLKEADGIVSMEL

Download         Length: 1296 bp

Antitoxin


Download         Length: 59 a.a.        Molecular weight: 6476.39 Da        Isoelectric Point: 10.5679

>AT293711 WP_095140675.1 NZ_LT906457:c81544-81368 [Legionella spiritensis]
MRQKAGLTQEELAQRMGTQKGNISRLEKGSSNPSWKTLEKYAHACGFDISMAFKRTAS

Download         Length: 177 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References