Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2430435..2431077 Replicon chromosome
Accession NZ_LT906456
Organism Actinobacillus suis strain NCTC12996

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag CKV75_RS11375 Protein ID WP_005621659.1
Coordinates 2430435..2430806 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag CKV75_RS11380 Protein ID WP_005621656.1
Coordinates 2430787..2431077 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV75_RS11360 2426940..2427794 + 855 WP_015674480.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
CKV75_RS11365 2427838..2428407 - 570 WP_005608594.1 elongation factor P hydroxylase -
CKV75_RS11370 2428466..2430217 - 1752 WP_015674481.1 protein-disulfide reductase DsbD -
CKV75_RS11375 2430435..2430806 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKV75_RS11380 2430787..2431077 + 291 WP_005621656.1 helix-turn-helix transcriptional regulator Antitoxin
CKV75_RS11385 2431145..2432107 - 963 WP_015674482.1 calcium/sodium antiporter -
CKV75_RS11390 2432180..2432677 + 498 WP_015674483.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
CKV75_RS11395 2432905..2433639 + 735 WP_015674484.1 arginine ABC transporter ATP-binding protein ArtP -
CKV75_RS11400 2433659..2434378 + 720 WP_015674485.1 transporter substrate-binding domain-containing protein -
CKV75_RS11405 2434384..2435055 + 672 WP_015674486.1 arginine ABC transporter permease ArtQ -
CKV75_RS11410 2435055..2435738 + 684 WP_015674487.1 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T293710 WP_005621659.1 NZ_LT906456:2430435-2430806 [Actinobacillus suis]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10803.58 Da        Isoelectric Point: 8.7274

>AT293710 WP_005621656.1 NZ_LT906456:2430787-2431077 [Actinobacillus suis]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARVEKGSSNPSLGTLLKLLVP
LGKTLQIVPLDDTHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References