Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1994585..1996242 Replicon chromosome
Accession NZ_LT906456
Organism Actinobacillus suis strain NCTC12996

Toxin (Protein)


Gene name hipA Uniprot ID K0FZC7
Locus tag CKV75_RS09250 Protein ID WP_015674102.1
Coordinates 1994911..1996242 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID K0G670
Locus tag CKV75_RS09245 Protein ID WP_015674101.1
Coordinates 1994585..1994914 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV75_RS09230 1990972..1992252 + 1281 WP_015674098.1 threonine synthase -
CKV75_RS09235 1992330..1992668 + 339 WP_015674099.1 hypothetical protein -
CKV75_RS09240 1992966..1994291 - 1326 WP_015674100.1 MFS transporter family glucose-6-phosphate receptor UhpC -
CKV75_RS09245 1994585..1994914 - 330 WP_015674101.1 helix-turn-helix domain-containing protein Antitoxin
CKV75_RS09250 1994911..1996242 - 1332 WP_015674102.1 type II toxin-antitoxin system HipA family toxin Toxin
CKV75_RS09255 1996639..1997667 + 1029 Protein_1786 Abi family protein -
CKV75_RS09260 1997824..1998861 - 1038 WP_015674105.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(164-387)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51155.04 Da        Isoelectric Point: 5.1273

>T293708 WP_015674102.1 NZ_LT906456:c1996242-1994911 [Actinobacillus suis]
MSDISIKIKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANARSISINYPVNVFIDHADKLMTTLADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAVPEIQSERYFPLNVVQNRQSDFLEYANQTGAIVGG
ATGAGGEAPKLLLKRQDKQVWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEG
ERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYGGNLDHEQTIRNLLNVISASQFSNDFDNRHFVIEWVKRDLLNIAF
GNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGIIRTTTWAKNGDNSQEFAGEYRFDKIADSLSDLIEPDILLRELR
MLATQLVDLKSRLTKRGVPKSILDFPAIGFDYLPEKLQRWGLV

Download         Length: 1332 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12364.46 Da        Isoelectric Point: 10.6799

>AT293708 WP_015674101.1 NZ_LT906456:c1994914-1994585 [Actinobacillus suis]
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMDSFLK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0FZC7

Antitoxin

Source ID Structure
AlphaFold DB K0G670

References