Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1930996..1931727 Replicon chromosome
Accession NZ_LT906456
Organism Actinobacillus suis strain NCTC12996

Toxin (Protein)


Gene name tacT Uniprot ID K0FZ70
Locus tag CKV75_RS08910 Protein ID WP_015674046.1
Coordinates 1930996..1931463 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID K0G6P2
Locus tag CKV75_RS08915 Protein ID WP_015674047.1
Coordinates 1931467..1931727 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV75_RS08895 1926938..1928314 + 1377 WP_015674043.1 Trk system potassium transporter TrkA -
CKV75_RS08900 1928527..1929921 + 1395 WP_015674044.1 class II fumarate hydratase -
CKV75_RS08905 1930032..1930913 - 882 WP_015674045.1 50S ribosomal protein L11 methyltransferase -
CKV75_RS08910 1930996..1931463 - 468 WP_015674046.1 GNAT family N-acetyltransferase Toxin
CKV75_RS08915 1931467..1931727 - 261 WP_015674047.1 DUF1778 domain-containing protein Antitoxin
CKV75_RS08920 1931848..1933308 - 1461 WP_015674048.1 metalloprotease TldD -
CKV75_RS08925 1933438..1934697 + 1260 WP_015674049.1 tRNA lysidine(34) synthetase TilS -
CKV75_RS08930 1934798..1935298 - 501 WP_015674050.1 thiol peroxidase -
CKV75_RS08935 1935431..1936156 + 726 WP_015674051.1 1-acylglycerol-3-phosphate O-acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17157.14 Da        Isoelectric Point: 8.9515

>T293707 WP_015674046.1 NZ_LT906456:c1931463-1930996 [Actinobacillus suis]
MHAPELLSEQHIVQHFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSRQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9826.17 Da        Isoelectric Point: 4.4883

>AT293707 WP_015674047.1 NZ_LT906456:c1931727-1931467 [Actinobacillus suis]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQTFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0FZ70

Antitoxin

Source ID Structure
AlphaFold DB K0G6P2

References