Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 524541..526099 Replicon chromosome
Accession NZ_LT906456
Organism Actinobacillus suis strain NCTC12996

Toxin (Protein)


Gene name hipA Uniprot ID K0FW50
Locus tag CKV75_RS02410 Protein ID WP_014991250.1
Coordinates 524777..526099 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID K0G332
Locus tag CKV75_RS02405 Protein ID WP_014991249.1
Coordinates 524541..524783 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV75_RS02400 520809..524417 + 3609 WP_014991248.1 exodeoxyribonuclease V subunit beta -
CKV75_RS02405 524541..524783 + 243 WP_014991249.1 helix-turn-helix domain-containing protein Antitoxin
CKV75_RS02410 524777..526099 + 1323 WP_014991250.1 HipA domain-containing protein Toxin
CKV75_RS02415 526163..527413 - 1251 WP_014991251.1 NupC/NupG family nucleoside CNT transporter -
CKV75_RS02420 527453..528241 - 789 WP_014991252.1 4Fe-4S cluster-binding domain-containing protein -
CKV75_RS02425 528243..529787 - 1545 WP_014991253.1 YjjI family glycine radical enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50395.13 Da        Isoelectric Point: 8.3234

>T293705 WP_014991250.1 NZ_LT906456:524777-526099 [Actinobacillus suis]
MVKCLCVLMNGELVGFFERTMSGSHLFRYADEWFLSPNVRPISLSMPLRREVYQGKEVINFFDNLLPDHPQVRARIAARF
QAETQQPFELLAKIGRDATGAITLLEENTEIPNHKVIYATELNENELHSLLLGYQQNAPLGMLDEAQDFRISIAGAQEKT
ALLWYNERWQLPHGLTPTTHIIKLPIGKIQTPKYQLDLSQSVDNELICLRLCAAFGLPTANVNLLEVGDVRALVVERFDR
KLHSSNKYFLRLPYEDFCQVFGLAPTQKYESDGGIGIRHIMDKLLYSSHTSDRAQFMKTQFLFWVLGAIDGHAKNFSIAL
KSQSRYHLSPIYDVISAYPMLGGKGWHQSDLQLAMSLYSTQKGKKWSWQKIRPVHYLSTAKSVGFNQLEMKHIIEEISDT
ALKKLDFVADRLPININEQVRDQIFNGVKKQIDKIKLDRI

Download         Length: 1323 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9379.79 Da        Isoelectric Point: 8.6782

>AT293705 WP_014991249.1 NZ_LT906456:524541-524783 [Actinobacillus suis]
MLINDPNSLAVYLRDIRKQQKQSQKMIAQRVGLRQATISTFEAQPDKVTIETLFKIVHSLGLEIHLEEKHTNMFNRSDEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0FW50

Antitoxin

Source ID Structure
AlphaFold DB K0G332

References