Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-YefM
Location 90005..90714 Replicon chromosome
Accession NZ_LT906456
Organism Actinobacillus suis strain NCTC12996

Toxin (Protein)


Gene name vapC Uniprot ID K0G9D3
Locus tag CKV75_RS00495 Protein ID WP_014990917.1
Coordinates 90292..90714 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID K0G3K1
Locus tag CKV75_RS00490 Protein ID WP_014990916.1
Coordinates 90005..90292 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV75_RS00475 85404..86585 + 1182 WP_014990913.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
CKV75_RS00480 86640..87188 + 549 WP_014990914.1 type IV pilus biogenesis/stability protein PilW -
CKV75_RS00485 87264..89603 + 2340 WP_014990915.1 RNA-binding transcriptional accessory protein -
CKV75_RS00490 90005..90292 + 288 WP_014990916.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CKV75_RS00495 90292..90714 + 423 WP_014990917.1 type II toxin-antitoxin system VapC family toxin Toxin
CKV75_RS00500 91089..92369 - 1281 WP_014990918.1 NAD(P)/FAD-dependent oxidoreductase -
CKV75_RS00505 92481..92999 - 519 WP_179130574.1 SprT family zinc-dependent metalloprotease -
CKV75_RS00510 93000..93770 - 771 WP_014990920.1 ribonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16233.07 Da        Isoelectric Point: 9.0431

>T293704 WP_014990917.1 NZ_LT906456:90292-90714 [Actinobacillus suis]
MYLLDTNIVSELRKMESGKADVNVVAWFQQVNLTDAYLSVITLFEIKLGILQLKRKDIQQAKLLQSWFEQKLLHHFENRI
LPLDTKVMMICAEFHIPDKKPLNDSYIAATAKAHRFKIVTRNVKNFKGCGVEVLNPFIDE

Download         Length: 423 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10623.95 Da        Isoelectric Point: 5.0203

>AT293704 WP_014990916.1 NZ_LT906456:90005-90292 [Actinobacillus suis]
MAVISSKEFNQRASAVLKIAETEPVYITKWGKVVSVLASYAHYQAQTKSQSLADAFSSTVPTAILSTEAEQQFEQTLQQI
RQQSKMNVPDLSEWE

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0G9D3

Antitoxin

Source ID Structure
AlphaFold DB K0G3K1

References