Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1580271..1580863 Replicon chromosome
Accession NZ_LT906455
Organism Aliarcobacter butzleri strain NCTC 12481

Toxin (Protein)


Gene name hicA Uniprot ID A8EV40
Locus tag CKV87_RS07830 Protein ID WP_012013194.1
Coordinates 1580271..1580495 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A8EV41
Locus tag CKV87_RS07835 Protein ID WP_012013195.1
Coordinates 1580519..1580863 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV87_RS07815 1575961..1576584 - 624 WP_041644966.1 DJ-1/PfpI family protein -
CKV87_RS07820 1576783..1577442 + 660 WP_004509797.1 methyltransferase domain-containing protein -
CKV87_RS07825 1577722..1580103 - 2382 WP_012013193.1 TonB-dependent siderophore receptor -
CKV87_RS07830 1580271..1580495 + 225 WP_012013194.1 type II toxin-antitoxin system HicA family toxin Toxin
CKV87_RS07835 1580519..1580863 + 345 WP_012013195.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CKV87_RS07840 1580868..1581842 - 975 WP_012013196.1 FecR domain-containing protein -
CKV87_RS07845 1581843..1582316 - 474 WP_012013197.1 sigma-70 family RNA polymerase sigma factor -
CKV87_RS07850 1582453..1583514 + 1062 WP_012013198.1 agmatinase family protein -
CKV87_RS07855 1583537..1584838 - 1302 WP_012013199.1 2-isopropylmalate synthase -
CKV87_RS07860 1585019..1585804 - 786 WP_012013200.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-74)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8537.26 Da        Isoelectric Point: 10.2447

>T293703 WP_012013194.1 NZ_LT906455:1580271-1580495 [Aliarcobacter butzleri]
MSKKDKLLIKFLEIPPRKDLTFKELSTLLISLGFEKIEGAGSAVKFYNKEKDLLINLHKPHPSDILKVYLIKQI

Download         Length: 225 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13032.76 Da        Isoelectric Point: 4.8950

>AT293703 WP_012013195.1 NZ_LT906455:1580519-1580863 [Aliarcobacter butzleri]
MSNIIEYNGYIGTIEYSQEDKCFFGKIDMINDLITFEAQNATELEENFKNAVDEYVQTCKQLNREPQKAFKGVFNVRTGS
ELHRLAVLNATKIGVSLNTYIKSLIEKDNKLSLN

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A8EV40

Antitoxin

Source ID Structure
AlphaFold DB A8EV41

References