Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 1370624..1371894 | Replicon | chromosome |
| Accession | NZ_LT906454 | ||
| Organism | Streptococcus acidominimus strain NCTC11291 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | A0A0Z8INM2 |
| Locus tag | CKV85_RS06680 | Protein ID | WP_024409332.1 |
| Coordinates | 1370624..1371418 (-) | Length | 265 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | CKV85_RS06685 | Protein ID | WP_024409333.1 |
| Coordinates | 1371418..1371894 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CKV85_RS06665 | 1366072..1366662 | - | 591 | WP_095123716.1 | hypothetical protein | - |
| CKV85_RS06670 | 1366703..1368628 | - | 1926 | WP_044769862.1 | ATP-dependent helicase | - |
| CKV85_RS06675 | 1368610..1370643 | - | 2034 | WP_095122928.1 | ATP-dependent endonuclease | - |
| CKV85_RS06680 | 1370624..1371418 | - | 795 | WP_024409332.1 | zeta toxin family protein | Toxin |
| CKV85_RS06685 | 1371418..1371894 | - | 477 | WP_024409333.1 | helix-turn-helix domain-containing protein | Antitoxin |
| CKV85_RS06690 | 1371964..1372248 | - | 285 | WP_095122930.1 | hypothetical protein | - |
| CKV85_RS06695 | 1372292..1372687 | - | 396 | WP_017285409.1 | hypothetical protein | - |
| CKV85_RS06700 | 1372691..1372918 | - | 228 | WP_024409335.1 | hypothetical protein | - |
| CKV85_RS06705 | 1372972..1374063 | - | 1092 | WP_095122932.1 | toprim domain-containing protein | - |
| CKV85_RS06710 | 1374103..1374741 | - | 639 | WP_095122934.1 | peptidylprolyl isomerase | - |
| CKV85_RS06715 | 1374852..1375141 | - | 290 | Protein_1322 | hypothetical protein | - |
| CKV85_RS06720 | 1375156..1375455 | - | 300 | WP_024382151.1 | hypothetical protein | - |
| CKV85_RS06725 | 1375525..1376436 | - | 912 | WP_032505215.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(O) | - | 1349716..1444125 | 94409 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 265 a.a. Molecular weight: 30360.57 Da Isoelectric Point: 6.6151
>T293702 WP_024409332.1 NZ_LT906454:c1371418-1370624 [Streptococcus acidominimus]
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN
MRLEEFSKDDFDLALKRTIRSLTRGKTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLTLQE
EYGKDSVDYTKGFAGKMVEQLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPNQARATPKEHHDGIVNHLVDNLRELENDHLFDYIQIYQRDRSCVYDSETDDGSAAEVLQECLFGKWSKVEEEMM
KMGQELLMEFLEMKKGRIYENKKN
Download Length: 795 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18119.46 Da Isoelectric Point: 4.3193
>AT293702 WP_024409333.1 NZ_LT906454:c1371894-1371418 [Streptococcus acidominimus]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSLSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSELYRYQDSQGITFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELANHQVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|