Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1216159..1216634 Replicon chromosome
Accession NZ_LT906454
Organism Streptococcus acidominimus strain NCTC11291

Toxin (Protein)


Gene name relE Uniprot ID V6Z0S2
Locus tag CKV85_RS05955 Protein ID WP_017769462.1
Coordinates 1216159..1216422 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V6Z151
Locus tag CKV85_RS05960 Protein ID WP_017769463.1
Coordinates 1216419..1216634 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV85_RS05935 1212146..1212637 + 492 WP_017769385.1 PASTA domain-containing protein -
CKV85_RS05940 1212840..1214126 - 1287 WP_172843176.1 IS110 family transposase -
CKV85_RS05945 1214362..1214655 - 294 Protein_1172 MetQ/NlpA family ABC transporter substrate-binding protein -
CKV85_RS05950 1214728..1215732 + 1005 WP_095122758.1 IS5 family transposase -
CKV85_RS05955 1216159..1216422 - 264 WP_017769462.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKV85_RS05960 1216419..1216634 - 216 WP_017769463.1 hypothetical protein Antitoxin
CKV85_RS05965 1217259..1218428 - 1170 WP_095122760.1 ATP-grasp domain-containing protein -
CKV85_RS05970 1218450..1219196 - 747 WP_095122763.1 esterase family protein -
CKV85_RS05975 1219218..1220042 - 825 WP_095122765.1 alpha/beta hydrolase -
CKV85_RS05980 1220144..1221016 - 873 Protein_1179 winged helix DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-69)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10396.92 Da        Isoelectric Point: 10.1763

>T293701 WP_017769462.1 NZ_LT906454:c1216422-1216159 [Streptococcus acidominimus]
MIYQVRLTSKADKQLRKLDAYTRNTILAWIKKNLYQTDNPRLHGKGLTANHSGEWRYRVGNYRILANIYDDEIVIEIFTI
GHRRDIY

Download         Length: 264 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8310.38 Da        Isoelectric Point: 4.0414

>AT293701 WP_017769463.1 NZ_LT906454:c1216634-1216419 [Streptococcus acidominimus]
MTTMTLRINDEDSNLIKNYIKLHGLSISEFARQSMLERIEDEYDLAVLRQAMSEDDSIRIPVEDLFEEFGI

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6Z0S2

Antitoxin

Source ID Structure
AlphaFold DB V6Z151

References