Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 315676..316288 Replicon chromosome
Accession NZ_LT906454
Organism Streptococcus acidominimus strain NCTC11291

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag CKV85_RS01565 Protein ID WP_095121639.1
Coordinates 315676..316011 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID V6Z120
Locus tag CKV85_RS01570 Protein ID WP_017769573.1
Coordinates 316001..316288 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV85_RS01545 311846..312689 + 844 Protein_283 replication initiation protein -
CKV85_RS01550 312725..313159 + 435 WP_095121635.1 hypothetical protein -
CKV85_RS01555 313476..314731 + 1256 Protein_285 plasmid recombination protein -
CKV85_RS01560 314904..315377 + 474 WP_095121637.1 hypothetical protein -
CKV85_RS01565 315676..316011 - 336 WP_095121639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKV85_RS01570 316001..316288 - 288 WP_017769573.1 hypothetical protein Antitoxin
CKV85_RS01575 316634..316995 + 362 Protein_289 transposase -
CKV85_RS01580 317034..317282 + 249 WP_095123687.1 hypothetical protein -
CKV85_RS01585 317592..319136 + 1545 WP_095121641.1 type I restriction-modification system subunit M -
CKV85_RS01590 319138..320346 + 1209 WP_172843136.1 restriction endonuclease subunit S -
CKV85_RS11775 320351..320887 + 537 WP_172843137.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 307048..326970 19922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13228.05 Da        Isoelectric Point: 5.2217

>T293700 WP_095121639.1 NZ_LT906454:c316011-315676 [Streptococcus acidominimus]
MDYKKYQIIYAPDILEKLKEIHDYISQNYSSISAQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEEGRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10949.57 Da        Isoelectric Point: 4.9341

>AT293700 WP_017769573.1 NZ_LT906454:c316288-316001 [Streptococcus acidominimus]
MVTAEKKRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRTELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6Z120

References