Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 2413113..2413652 Replicon chromosome
Accession NC_021082
Organism Mannheimia haemolytica M42548

Toxin (Protein)


Gene name relE Uniprot ID A0A248ZYA9
Locus tag MHH_RS26235 Protein ID WP_006247804.1
Coordinates 2413383..2413652 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A547E920
Locus tag MHH_RS26230 Protein ID WP_006247803.1
Coordinates 2413113..2413379 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHH_RS26190 2408513..2409148 - 636 Protein_2408 transposase -
MHH_RS26195 2409249..2409959 - 711 Protein_2409 tyrosine-type recombinase/integrase -
MHH_RS28145 2409863..2410186 - 324 WP_006253316.1 helix-turn-helix domain-containing protein -
MHH_RS26200 2410267..2410434 - 168 WP_006253314.1 DNA cytosine methyltransferase -
MHH_RS26205 2410442..2410816 - 375 WP_006247798.1 hypothetical protein -
MHH_RS28150 2410966..2411193 + 228 Protein_2413 phage terminase large subunit family protein -
MHH_RS26210 2411218..2411613 + 396 WP_006247799.1 phage tail protein -
MHH_RS26215 2411645..2412286 + 642 WP_006247800.1 hypothetical protein -
MHH_RS26220 2412369..2412770 + 402 WP_006247801.1 hypothetical protein -
MHH_RS26225 2412815..2413045 + 231 WP_006247802.1 DUF4035 domain-containing protein -
MHH_RS26230 2413113..2413379 + 267 WP_006247803.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MHH_RS26235 2413383..2413652 + 270 WP_006247804.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
MHH_RS26240 2413727..2413990 + 264 WP_006247805.1 hypothetical protein -
MHH_RS26245 2414050..2414760 + 711 WP_006253312.1 tape measure protein -
MHH_RS26250 2414738..2415028 + 291 Protein_2422 C40 family peptidase -
MHH_RS26255 2415018..2415737 + 720 WP_006247806.1 preprotein translocase subunit YajC -
MHH_RS26265 2415959..2416585 + 627 WP_006247807.1 tail assembly protein -
MHH_RS26270 2416634..2417245 + 612 WP_006253310.1 hypothetical protein -
MHH_RS26275 2417356..2418042 + 687 WP_006247808.1 hypothetical protein -
MHH_RS28520 2418052..2418210 + 159 WP_006247809.1 hypothetical protein -
MHH_RS26280 2418219..2418518 - 300 WP_006247810.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2400500..2424706 24206
- flank IS/Tn - - 2408456..2409148 692


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-75)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10278.90 Da        Isoelectric Point: 6.2121

>T29370 WP_006247804.1 NC_021082:2413383-2413652 [Mannheimia haemolytica M42548]
MLQISPTNAYKRDFKKIAAELVGSSEYVEVMYCLINQLPLAEKYRDHPLQGEWQGFRDCHIKPDLVLIYAVEDNLLRLVR
LGSHAELFG

Download         Length: 270 bp

>T29370 NC_021082:2413383-2413652 [Mannheimia haemolytica M42548]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9913.38 Da        Isoelectric Point: 7.0082

>AT29370 WP_006247803.1 NC_021082:2413113-2413379 [Mannheimia haemolytica M42548]
MATINDAFSFRTNTEIKNTAFDVIKNYGMTPSQVFNMFLTEIAKTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYASLEA
FHKAMLAE

Download         Length: 267 bp

>AT29370 NC_021082:2413113-2413379 [Mannheimia haemolytica M42548]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248ZYA9

Antitoxin

Source ID Structure
AlphaFold DB A0A547E920

References