Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelB-YoeB
Location 1997939..1998444 Replicon chromosome
Accession NZ_LT906451
Organism Legionella lansingensis strain NCTC12830

Toxin (Protein)


Gene name relE Uniprot ID A0A0W0VMW3
Locus tag CKV79_RS09045 Protein ID WP_028373807.1
Coordinates 1997939..1998193 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0W0VNC1
Locus tag CKV79_RS09050 Protein ID WP_028373806.1
Coordinates 1998190..1998444 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV79_RS09030 1993590..1994336 - 747 WP_051546209.1 tRNA-dependent cyclodipeptide synthase -
CKV79_RS09035 1994693..1995673 + 981 WP_028373809.1 TauD/TfdA family dioxygenase -
CKV79_RS09040 1996164..1997723 + 1560 WP_035915868.1 MFS transporter -
CKV79_RS09045 1997939..1998193 + 255 WP_028373807.1 type II toxin-antitoxin system prevent-host-death family antitoxin Toxin
CKV79_RS09050 1998190..1998444 + 255 WP_028373806.1 Txe/YoeB family addiction module toxin Antitoxin
CKV79_RS09055 1998654..1999595 + 942 WP_028373805.1 ABC transporter substrate-binding protein -
CKV79_RS09060 1999599..2000669 + 1071 WP_028373804.1 glycine oxidase ThiO -
CKV79_RS09065 2000666..2000869 + 204 WP_028373803.1 sulfur carrier protein ThiS -
CKV79_RS09070 2000874..2001662 + 789 WP_028373802.1 thiazole synthase -
CKV79_RS09075 2001659..2003155 + 1497 WP_065236361.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9407.65 Da        Isoelectric Point: 4.6234

>T293696 WP_028373807.1 NZ_LT906451:1997939-1998193 [Legionella lansingensis]
MDVLSYSALRNNLASILDKVNEDHVSILITRQNGKPAVIMSLEDFKSYEETAYLMSSPKNVERLNQAIAEVEAGKTKEHG
IIEE

Download         Length: 255 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 10364.82 Da        Isoelectric Point: 8.0677

>AT293696 WP_028373806.1 NZ_LT906451:1998190-1998444 [Legionella lansingensis]
MILSWAENAWEDYLYWQATDKKMIKRINALIKDIQRHPFDGIGDPEPLKHHWSGYWSRRIDREHRIIYKATDEALYIVQC
RYHY

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0VMW3

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0VNC1

References