Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1042190..1042704 Replicon chromosome
Accession NZ_LT906447
Organism Staphylococcus piscifermentans strain NCTC13836

Toxin (Protein)


Gene name mazF Uniprot ID A0A3G4R0E2
Locus tag CKV71_RS04670 Protein ID WP_075140914.1
Coordinates 1042354..1042704 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID B9DMI8
Locus tag CKV71_RS04665 Protein ID WP_015900820.1
Coordinates 1042190..1042357 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV71_RS04640 1038184..1038573 + 390 WP_167376363.1 PH domain-containing protein -
CKV71_RS04645 1038566..1040047 + 1482 WP_095104342.1 PH domain-containing protein -
CKV71_RS04650 1040052..1040537 + 486 WP_095107238.1 PH domain-containing protein -
CKV71_RS04655 1040539..1040892 + 354 WP_095104344.1 holo-ACP synthase -
CKV71_RS04660 1040955..1042109 + 1155 WP_095104346.1 alanine racemase -
CKV71_RS04665 1042190..1042357 + 168 WP_015900820.1 hypothetical protein Antitoxin
CKV71_RS04670 1042354..1042704 + 351 WP_075140914.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CKV71_RS04675 1043018..1044019 + 1002 WP_095104348.1 PP2C family protein-serine/threonine phosphatase -
CKV71_RS04680 1044095..1044421 + 327 WP_095104350.1 anti-sigma factor antagonist -
CKV71_RS04685 1044423..1044902 + 480 WP_095104352.1 anti-sigma B factor RsbW -
CKV71_RS04690 1044877..1045647 + 771 WP_047133044.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13075.18 Da        Isoelectric Point: 10.0708

>T293694 WP_075140914.1 NZ_LT906447:1042354-1042704 [Staphylococcus piscifermentans]
MMRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TVDKKRLKEKLTYLSDEKMKEIDNAIQISLGLTHRN

Download         Length: 351 bp

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6211.75 Da        Isoelectric Point: 3.6836

>AT293694 WP_015900820.1 NZ_LT906447:1042190-1042357 [Staphylococcus piscifermentans]
MSTFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFSVECEACDCNESYLAFDKDE

Download         Length: 168 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G4R0E2

Antitoxin

Source ID Structure
AlphaFold DB A0A380F5Y4

References