Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 806258..806768 Replicon chromosome
Accession NZ_LT906446
Organism Megamonas hypermegale strain NCTC10570

Toxin (Protein)


Gene name yoeB Uniprot ID A0A239TIP8
Locus tag CKV65_RS03785 Protein ID WP_027889588.1
Coordinates 806508..806768 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A239TI60
Locus tag CKV65_RS03780 Protein ID WP_027889589.1
Coordinates 806258..806515 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV65_RS03765 804185..804532 - 348 WP_027889592.1 helix-turn-helix transcriptional regulator -
CKV65_RS03770 804662..805519 - 858 WP_051177575.1 DUF4261 domain-containing protein -
CKV65_RS03775 805597..805953 - 357 WP_027889590.1 DUF1292 domain-containing protein -
CKV65_RS03780 806258..806515 + 258 WP_027889589.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CKV65_RS03785 806508..806768 + 261 WP_027889588.1 Txe/YoeB family addiction module toxin Toxin
CKV65_RS03790 806908..807447 + 540 WP_036254418.1 Uma2 family endonuclease -
CKV65_RS03795 807787..809364 - 1578 WP_027889587.1 phosphoenolpyruvate carboxykinase (ATP) -
CKV65_RS03800 809602..810933 - 1332 WP_036254416.1 threonine/serine exporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10414.98 Da        Isoelectric Point: 9.3645

>T293692 WP_027889588.1 NZ_LT906446:806508-806768 [Megamonas hypermegale]
MNKLWSDRAWDDYLYWQFQDKKTLKKINDLIKDIERNGLSEGIGKPEPLKYKNVWSRRIDKENRLVYNIVGEDLWIIACR
GHYISL

Download         Length: 261 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9773.27 Da        Isoelectric Point: 6.9775

>AT293692 WP_027889589.1 NZ_LT906446:806258-806515 [Megamonas hypermegale]
MLAVNYSTIRSKLKTYCDEATDNNQTIIVTRKAEKNVVILSLEKYNRLMKIVQNAEYLSMIDRGIKQLEAGKGQKHDLIE
VDLDE

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A239TIP8

Antitoxin

Source ID Structure
AlphaFold DB A0A239TI60

References