293690

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 903283..903912 Replicon chromosome
Accession NZ_LT906444
Organism Listeria welshimeri strain NCTC11857

Toxin (Protein)


Gene name pemK Uniprot ID A0A6Z2PJ29
Locus tag CKV90_RS04475 Protein ID WP_031695189.1
Coordinates 903565..903912 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7U7S1X0
Locus tag CKV90_RS04470 Protein ID WP_003766128.1
Coordinates 903283..903561 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV90_RS04450 898585..900066 + 1482 WP_011701701.1 PH domain-containing protein -
CKV90_RS04455 900215..901603 + 1389 WP_011701702.1 protoporphyrinogen oxidase -
CKV90_RS04460 901596..901952 + 357 WP_011701703.1 holo-ACP synthase -
CKV90_RS04465 901971..903077 + 1107 WP_011701704.1 alanine racemase -
CKV90_RS04470 903283..903561 + 279 WP_003766128.1 CopG family ribbon-helix-helix protein Antitoxin
CKV90_RS04475 903565..903912 + 348 WP_031695189.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CKV90_RS04480 904160..904996 + 837 WP_011701705.1 STAS domain-containing protein -
CKV90_RS04485 905002..905358 + 357 WP_003721457.1 STAS domain-containing protein -
CKV90_RS04490 905361..905771 + 411 WP_011701706.1 anti-sigma regulatory factor -
CKV90_RS04495 905788..906792 + 1005 WP_011701707.1 PP2C family protein-serine/threonine phosphatase -
CKV90_RS04500 906941..907285 + 345 WP_011701708.1 anti sigma b factor antagonist RsbV -
CKV90_RS04505 907269..907742 + 474 WP_011701709.1 anti-sigma B factor RsbW -
CKV90_RS04510 907720..908499 + 780 WP_011701710.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.89 Da        Isoelectric Point: 7.2038

>T293690 WP_031695189.1 NZ_LT906444:903565-903912 [Listeria welshimeri]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNKALEVSLGVVEF

Download         Length: 348 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10575.05 Da        Isoelectric Point: 4.2980

>AT293690 WP_003766128.1 NZ_LT906444:903283-903561 [Listeria welshimeri]
VLEKEKRTIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6Z2PJ29

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7S1X0

References