Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prpT-prpA/CC2985(antitoxin)
Location 2454039..2454579 Replicon chromosome
Accession NZ_LT906442
Organism Legionella waltersii strain NCTC13017

Toxin (Protein)


Gene name PrpT Uniprot ID A0A0W1AP15
Locus tag CKW04_RS11335 Protein ID WP_058478937.1
Coordinates 2454283..2454579 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PrpA Uniprot ID A0A0W1AP56
Locus tag CKW04_RS11330 Protein ID WP_014844323.1
Coordinates 2454039..2454293 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW04_RS11300 2449609..2450907 + 1299 WP_058478940.1 hydroxymethylglutaryl-CoA reductase, degradative -
CKW04_RS11305 2450904..2451782 + 879 WP_058478939.1 hypothetical protein -
CKW04_RS11325 2452435..2453766 + 1332 WP_058478938.1 hypothetical protein -
CKW04_RS11330 2454039..2454293 + 255 WP_014844323.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CKW04_RS11335 2454283..2454579 + 297 WP_058478937.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CKW04_RS11340 2454844..2458953 - 4110 WP_058478936.1 ankyrin repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11551.17 Da        Isoelectric Point: 6.4763

>T293687 WP_058478937.1 NZ_LT906442:2454283-2454579 [Legionella waltersii]
MSNKTYRLYPKAVEDLESIYLYSTNEFGIKQTEDYILTIDLSFQRLADDPVIARKCDYIRPELHAFNVGSHIIFFKTTDY
GISVIRVLHQSMDFNRHL

Download         Length: 297 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9844.18 Da        Isoelectric Point: 9.5928

>AT293687 WP_014844323.1 NZ_LT906442:2454039-2454293 [Legionella waltersii]
MTRTMTVDLGNELRNYVESLVRSGDYRSNSEVLRESLRLLREKQAESKLEQLRHLIDEGEASGKPETWDAHDFLKKMKKK
SHVK

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W1AP15

Antitoxin

Source ID Structure
AlphaFold DB A0A0W1AP56

References