Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-ParD
Location 56351..56898 Replicon chromosome
Accession NZ_LT906441
Organism Cutibacterium granulosum strain NCTC11865

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CKV91_RS00280 Protein ID WP_065860579.1
Coordinates 56351..56662 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U1EU05
Locus tag CKV91_RS00285 Protein ID WP_021104869.1
Coordinates 56665..56898 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV91_RS00275 52589..56071 - 3483 WP_021105015.1 DNA-directed RNA polymerase subunit beta -
CKV91_RS00280 56351..56662 - 312 WP_065860579.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CKV91_RS00285 56665..56898 - 234 WP_021104869.1 ribbon-helix-helix domain-containing protein Antitoxin
CKV91_RS00290 57135..57530 - 396 WP_023034352.1 50S ribosomal protein L7/L12 -
CKV91_RS00295 57544..58155 - 612 WP_021105018.1 50S ribosomal protein L10 -
CKV91_RS00300 58590..59288 - 699 WP_021104866.1 50S ribosomal protein L1 -
CKV91_RS00305 59375..59806 - 432 WP_065860437.1 50S ribosomal protein L11 -
CKV91_RS00310 60069..61001 - 933 WP_065860436.1 transcription termination/antitermination protein NusG -
CKV91_RS09530 61027..61272 - 246 WP_197691367.1 preprotein translocase subunit SecE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11264.21 Da        Isoelectric Point: 8.5380

>T293685 WP_065860579.1 NZ_LT906441:c56662-56351 [Cutibacterium granulosum]
MREICLARMDRTRPVVVLTREVSRQAMTKVTVAPVTSTIKGLCSEVRVGKANGLDHESAIALDNVLTIPVDRLGRSIGFL
TPDQEKALARAFVMAYDLELPVA

Download         Length: 312 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8420.50 Da        Isoelectric Point: 4.1473

>AT293685 WP_021104869.1 NZ_LT906441:c56898-56665 [Cutibacterium granulosum]
MTTQISVRLPDEMVSFLDRCVSEGRVASRAEIIAGAVEREMRREAAMRDAAILAEVGSADDLDDLVAWSVEHPEMGS

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U1EU05

References