Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-ParD
Location 56351..56898 Replicon chromosome
Accession NZ_LT906441
Organism Cutibacterium granulosum strain NCTC11865

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CKV91_RS00280 Protein ID WP_065860579.1
Coordinates 56351..56662 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U1EU05
Locus tag CKV91_RS00285 Protein ID WP_021104869.1
Coordinates 56665..56898 (-) Length 78 a.a.

Genomic Context

CKV91_RS00275CKV91_RS00280CKV91_RS00285CKV91_RS00290CKV91_RS00295CKV91_RS00300CKV91_RS00305CKV91_RS00310CKV91_RS09530
Location: 52589..56071 (3483 bp)
Type: Others
Protein ID: WP_021105015.1
Location: 56351..56662 (312 bp)
Type: Toxin
Protein ID: WP_065860579.1
Location: 56665..56898 (234 bp)
Type: Antitoxin
Protein ID: WP_021104869.1
Location: 57135..57530 (396 bp)
Type: Others
Protein ID: WP_023034352.1
Location: 57544..58155 (612 bp)
Type: Others
Protein ID: WP_021105018.1
Location: 58590..59288 (699 bp)
Type: Others
Protein ID: WP_021104866.1
Location: 59375..59806 (432 bp)
Type: Others
Protein ID: WP_065860437.1
Location: 60069..61001 (933 bp)
Type: Others
Protein ID: WP_065860436.1
Location: 61027..61272 (246 bp)
Type: Others
Protein ID: WP_197691367.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CKV91_RS0027552589..56071-3483WP_021105015.1DNA-directed RNA polymerase subunit beta-
CKV91_RS0028056351..56662-312WP_065860579.1type II toxin-antitoxin system PemK/MazF family toxinToxin
CKV91_RS0028556665..56898-234WP_021104869.1ribbon-helix-helix domain-containing proteinAntitoxin
CKV91_RS0029057135..57530-396WP_023034352.150S ribosomal protein L7/L12-
CKV91_RS0029557544..58155-612WP_021105018.150S ribosomal protein L10-
CKV91_RS0030058590..59288-699WP_021104866.150S ribosomal protein L1-
CKV91_RS0030559375..59806-432WP_065860437.150S ribosomal protein L11-
CKV91_RS0031060069..61001-933WP_065860436.1transcription termination/antitermination protein NusG-
CKV91_RS0953061027..61272-246WP_197691367.1preprotein translocase subunit SecE-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11264.21 Da        Isoelectric Point: 8.5380

>T293685 WP_065860579.1 NZ_LT906441:c56662-56351 [Cutibacterium granulosum]
MREICLARMDRTRPVVVLTREVSRQAMTKVTVAPVTSTIKGLCSEVRVGKANGLDHESAIALDNVLTIPVDRLGRSIGFL
TPDQEKALARAFVMAYDLELPVA

Download         Length: 312 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8420.50 Da        Isoelectric Point: 4.1473

>AT293685 WP_021104869.1 NZ_LT906441:c56898-56665 [Cutibacterium granulosum]
MTTQISVRLPDEMVSFLDRCVSEGRVASRAEIIAGAVEREMRREAAMRDAAILAEVGSADDLDDLVAWSVEHPEMGS

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBU1EU05

References