Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 961212..961867 Replicon chromosome
Accession NZ_LT906437
Organism Neisseria gonorrhoeae strain NCTC13799

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag CKV86_RS05580 Protein ID WP_003691083.1
Coordinates 961212..961631 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag CKV86_RS05585 Protein ID WP_003688410.1
Coordinates 961631..961867 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV86_RS05560 956446..957987 - 1542 WP_003697015.1 multidrug efflux MFS transporter -
CKV86_RS05565 958135..958914 + 780 WP_003688416.1 (Fe-S)-binding protein -
CKV86_RS05570 958911..959612 + 702 WP_003688414.1 lactate utilization protein C -
CKV86_RS05575 959609..961063 + 1455 WP_003701282.1 iron-sulfur cluster-binding protein -
CKV86_RS05580 961212..961631 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
CKV86_RS05585 961631..961867 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
CKV86_RS05590 962073..962270 - 198 WP_033910354.1 IS3 family transposase -
CKV86_RS05595 962315..962893 - 579 WP_003688041.1 IS3 family transposase -
CKV86_RS05600 962898..963326 - 429 WP_003701165.1 helix-turn-helix domain-containing protein -
CKV86_RS05605 963538..963924 + 387 Protein_965 IS110 family transposase -
CKV86_RS05615 964307..965197 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
CKV86_RS05620 965208..966374 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
CKV86_RS05625 966446..966733 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T293681 WP_003691083.1 NZ_LT906437:c961631-961212 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT293681 WP_003688410.1 NZ_LT906437:c961867-961631 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References