Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4148369..4150205 Replicon chromosome
Accession NZ_LT906435
Organism Pandoraea sputorum strain NCTC13161

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CKW10_RS18130 Protein ID WP_084103905.1
Coordinates 4149297..4150205 (-) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag CKW10_RS18125 Protein ID WP_039403957.1
Coordinates 4148369..4149295 (-) Length 309 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW10_RS18105 4143591..4145087 - 1497 WP_039400225.1 aldehyde dehydrogenase -
CKW10_RS18110 4145101..4145919 - 819 WP_039400228.1 aspartate dehydrogenase -
CKW10_RS18115 4145912..4147564 - 1653 WP_039400230.1 thiamine pyrophosphate-binding protein -
CKW10_RS18120 4147557..4148372 - 816 WP_039400233.1 SDR family oxidoreductase -
CKW10_RS18125 4148369..4149295 - 927 WP_039403957.1 IclR family transcriptional regulator Antitoxin
CKW10_RS18130 4149297..4150205 - 909 WP_084103905.1 alpha/beta fold hydrolase Toxin
CKW10_RS18135 4150317..4150874 - 558 WP_039400236.1 cupin domain-containing protein -
CKW10_RS18140 4150915..4151688 - 774 WP_039403959.1 SDR family oxidoreductase -
CKW10_RS18145 4151743..4152525 - 783 WP_039400238.1 ABC transporter permease -
CKW10_RS18150 4152589..4153362 - 774 WP_039403960.1 ABC transporter ATP-binding protein -
CKW10_RS18155 4153770..4154846 - 1077 WP_039403961.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(52-281)

Antitoxin

Transcription regulator IclR, C-terminal

(163-286)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31536.69 Da        Isoelectric Point: 6.1504

>T293680 WP_084103905.1 NZ_LT906435:c4150205-4149297 [Pandoraea sputorum]
MQAEAHQHEVPEDDVVAPLRARLDAFPYRTVATRAGTVGYRCSGTGNDVGVPVVMLHGIGSGAASWLAQFEATGLDAKLY
AWDAPGYGETSNVAAAQPHPDAYADALEAWLDALGLDRVALAGHSLGAIMATRFASRAPQRVRGLFLCSPANGYGRADAE
VRVSKRDSRLAMLDKLGPAGMARERSDNLVAPGAADLPRAWVKWNMSRVLPVGYRQATHLLSNGDVAGDLAQYVSAKAGP
VAVAVGAQDGITPPAACEVIAKVAGVPLQIIDGAGHASYIETPDVLNAALAAWLERVAAGER

Download         Length: 909 bp

>T293680 NZ_LT906435:c4150205-4149297 [Pandoraea sputorum]
ATGCAAGCCGAAGCCCATCAACACGAAGTGCCAGAAGACGATGTCGTTGCGCCCTTGCGCGCACGGCTGGACGCCTTTCC
GTACCGCACCGTCGCAACGCGTGCGGGCACTGTCGGCTATCGCTGTTCGGGCACCGGGAACGACGTCGGCGTGCCGGTCG
TGATGCTGCACGGCATCGGCTCCGGCGCAGCGTCCTGGCTGGCGCAGTTCGAGGCCACGGGCCTCGACGCGAAGCTTTAC
GCATGGGATGCGCCCGGCTACGGCGAGACGTCGAATGTCGCTGCTGCGCAACCTCATCCCGACGCCTATGCCGACGCTCT
CGAAGCGTGGCTCGATGCCCTCGGTCTGGATCGTGTGGCGCTGGCCGGTCATTCGCTGGGCGCAATCATGGCAACGAGGT
TTGCGAGCCGCGCGCCGCAACGCGTACGCGGTCTCTTTCTGTGCTCTCCCGCCAACGGCTATGGCCGCGCCGATGCCGAG
GTGCGCGTGTCCAAGCGCGACAGCCGTCTGGCGATGCTCGACAAGCTCGGCCCTGCGGGCATGGCGCGTGAGCGCAGCGA
CAACCTCGTTGCGCCCGGCGCCGCCGATCTGCCACGCGCGTGGGTGAAATGGAACATGTCGCGGGTGCTGCCGGTCGGTT
ACCGTCAGGCGACGCACCTGCTCTCGAATGGCGATGTCGCGGGCGACCTTGCACAGTACGTGAGTGCCAAGGCCGGTCCC
GTTGCGGTCGCCGTGGGCGCGCAGGACGGCATCACGCCGCCTGCTGCGTGCGAGGTCATCGCGAAAGTGGCGGGCGTGCC
ACTGCAAATCATCGACGGCGCAGGCCACGCGTCGTACATCGAAACGCCGGACGTTCTGAATGCTGCGCTCGCCGCGTGGC
TCGAACGTGTCGCGGCAGGGGAGCGCTGA

Antitoxin


Download         Length: 309 a.a.        Molecular weight: 33707.48 Da        Isoelectric Point: 6.3628

>AT293680 WP_039403957.1 NZ_LT906435:c4149295-4148369 [Pandoraea sputorum]
MAPATPKREALTEDDNMQDDRNVSPDGDAVVEGPAESRYLVPGLERGLRILTQFSPREPVFSAPELSQRLGIPRTTVFRL
LQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSVAGVF
NSIKVNVGTRLPAHATVHGHVLMGDLTLTELRALYPEKTLEKFTPQTPESLTELFERVREDAERGYAVSASSFERGISVV
SAPVRNDVGRICAAITVTIPRANIDASMLDAGLIGQVREAADALSHRLNYRPGSDGKSTPYMKSLGLK

Download         Length: 927 bp

>AT293680 NZ_LT906435:c4149295-4148369 [Pandoraea sputorum]
ATGGCACCGGCCACACCGAAGCGCGAAGCGCTCACCGAAGACGACAATATGCAGGACGATCGAAACGTCTCGCCCGACGG
CGACGCTGTCGTCGAGGGCCCTGCCGAGTCCCGCTATCTCGTGCCGGGCCTAGAGCGCGGCCTGCGCATCCTCACCCAAT
TCTCGCCGCGCGAACCGGTGTTCAGTGCACCGGAACTGTCGCAACGGCTGGGCATTCCGCGCACGACCGTCTTCCGTCTG
CTGCAGACGCTCGAAGCCATGGGCTTTCTTGAGCGTGCGGGAAGCGAAAAGAACTTCCGTCTGGGCGTGGCCGTGCTGCG
TCTGGGCTTCGAATACCTCAGCTCGCTGGAACTGACCGACCTGGGCATTCCGATCATCGAGCGCCTGCGCGACGCCACGC
AACTGACGTCGCACATCGTGATTCGCGACGGCCGCGACATCGTGTTCGTCGCGAAGGCGCAAAGCGTCGCCGGCGTCTTC
AACTCGATCAAGGTCAACGTCGGCACGCGTCTGCCCGCGCACGCCACGGTGCACGGTCACGTGCTGATGGGCGATCTGAC
GCTCACCGAACTGCGCGCGCTGTATCCCGAGAAGACGCTGGAGAAATTCACGCCGCAGACGCCAGAGTCGCTCACCGAAC
TGTTCGAGCGTGTGCGCGAAGACGCCGAACGCGGCTATGCCGTGTCGGCCTCGTCGTTCGAGCGCGGCATCAGCGTGGTG
AGCGCGCCGGTGCGCAACGACGTGGGTCGCATCTGCGCCGCCATCACGGTCACGATTCCGCGCGCGAACATCGACGCATC
GATGCTCGACGCGGGCCTGATCGGTCAGGTGCGCGAAGCCGCCGATGCGCTCTCGCACCGTCTGAACTACCGCCCTGGCA
GCGACGGCAAGTCCACCCCCTACATGAAGTCACTGGGACTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References