Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1303083..1303733 Replicon chromosome
Accession NZ_LT906435
Organism Pandoraea sputorum strain NCTC13161

Toxin (Protein)


Gene name hicA Uniprot ID A0A239SBP3
Locus tag CKW10_RS05885 Protein ID WP_039396751.1
Coordinates 1303083..1303268 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A239SD75
Locus tag CKW10_RS05890 Protein ID WP_039396753.1
Coordinates 1303314..1303733 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKW10_RS05865 1298178..1299650 - 1473 WP_052252560.1 amino acid permease -
CKW10_RS05870 1299746..1300840 - 1095 WP_039396745.1 porin -
CKW10_RS05875 1301110..1301583 + 474 WP_039396747.1 Lrp/AsnC family transcriptional regulator -
CKW10_RS05880 1301650..1302837 + 1188 WP_039396749.1 alpha-hydroxy-acid oxidizing protein -
CKW10_RS05885 1303083..1303268 + 186 WP_039396751.1 type II toxin-antitoxin system HicA family toxin Toxin
CKW10_RS05890 1303314..1303733 + 420 WP_039396753.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CKW10_RS05895 1303759..1304187 - 429 WP_039396756.1 hypothetical protein -
CKW10_RS05900 1304307..1305278 - 972 WP_039396759.1 LysR family transcriptional regulator -
CKW10_RS05905 1305593..1306906 + 1314 WP_039396762.1 MFS transporter -
CKW10_RS05910 1306985..1307779 + 795 WP_039396765.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7022.03 Da        Isoelectric Point: 11.5775

>T293678 WP_039396751.1 NZ_LT906435:1303083-1303268 [Pandoraea sputorum]
MKYSEFRRWLRRHGATFEQHRAGSSHFRVTLNGRSTVFPDHGAKEIGQGLVEAIKKQLGLK

Download         Length: 186 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15529.07 Da        Isoelectric Point: 8.4824

>AT293678 WP_039396753.1 NZ_LT906435:1303314-1303733 [Pandoraea sputorum]
MLTYPITLKRDTNGTLLVTFPDVPEAITVGENEEDAREQALEALEAALEFYFAQKTPIPWPSRPKRGQATITLPIMASIK
VLLANEMIAQNVRKAELARRMHVNQVQVDRLLKLGYASRLDAVESAFAVLGKRLEVRAV

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A239SBP3

Antitoxin

Source ID Structure
AlphaFold DB A0A239SD75

References