Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1083443..1084029 Replicon chromosome
Accession NZ_LT906434
Organism Neisseria zoodegmatis strain NCTC12230

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CKV66_RS05015 Protein ID WP_085363875.1
Coordinates 1083775..1084029 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CKV66_RS05010 Protein ID WP_085363876.1
Coordinates 1083443..1083778 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKV66_RS04985 1079014..1079793 - 780 WP_085363879.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
CKV66_RS04990 1079955..1080461 + 507 WP_085363878.1 hemerythrin domain-containing protein -
CKV66_RS04995 1080920..1081858 - 939 WP_054598759.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
CKV66_RS05000 1081884..1082399 - 516 WP_054598760.1 lipoprotein signal peptidase -
CKV66_RS05005 1082553..1083329 + 777 WP_085363877.1 ferredoxin--NADP reductase -
CKV66_RS05010 1083443..1083778 - 336 WP_085363876.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CKV66_RS05015 1083775..1084029 - 255 WP_085363875.1 type II toxin-antitoxin system HicA family toxin Toxin
CKV66_RS05020 1084731..1085327 - 597 WP_085363874.1 DUF4276 family protein -
CKV66_RS05025 1085324..1086535 - 1212 WP_085363873.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9433.94 Da        Isoelectric Point: 10.5624

>T293672 WP_085363875.1 NZ_LT906434:c1084029-1083775 [Neisseria zoodegmatis]
MKKKHQRTLALIFNRPVSGSIKWADIEALFAELGAEIQEREGSRVAVILFGQVKVFHRPHPSLDTDKGAVASVRKWLEEN
GVKP

Download         Length: 255 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12031.44 Da        Isoelectric Point: 5.0956

>AT293672 WP_085363876.1 NZ_LT906434:c1083778-1083443 [Neisseria zoodegmatis]
MNNVMEINGHKAIIQYDPETELLRGEFVGLNGGADFYADNVADLHKEGAASLAVFLDVCKEKGIEPYKQYSGRFNVRISP
ETHAAAAAAAAAQNISLNEWVNRAISQSAHV

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References