Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4261259..4262040 Replicon chromosome
Accession NZ_LT905060
Organism Salmonella enterica subsp. enterica serovar Typhi isolate ISP_03_07467_SGB110-sc-1979083

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag CJZ88_RS21095 Protein ID WP_000626103.1
Coordinates 4261259..4261750 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag CJZ88_RS21100 Protein ID WP_001110456.1
Coordinates 4261747..4262040 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ88_RS21070 4257027..4258390 - 1364 Protein_4131 SPI-7-type island replicative DNA helicase -
CJZ88_RS21075 4258387..4259421 - 1035 WP_001195363.1 ParA family protein -
CJZ88_RS21080 4259635..4259709 - 75 Protein_4133 helix-turn-helix domain-containing protein -
CJZ88_RS21085 4260089..4260166 + 78 Protein_4134 porin family protein -
CJZ88_RS21090 4260266..4261018 + 753 WP_001785756.1 non-specific acid phosphatase -
CJZ88_RS21095 4261259..4261750 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
CJZ88_RS21100 4261747..4262040 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
CJZ88_RS21105 4262357..4262579 + 223 Protein_4138 hypothetical protein -
CJZ88_RS21110 4262845..4263720 + 876 WP_000921674.1 AraC family transcriptional regulator -
CJZ88_RS21115 4263717..4264004 + 288 WP_001269916.1 transcriptional regulator RtsB -
CJZ88_RS21120 4264027..4264243 + 217 Protein_4141 hypothetical protein -
CJZ88_RS21125 4264251..4264595 + 345 WP_100680417.1 Ig-like domain-containing protein -
CJZ88_RS21130 4264882..4265787 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T293669 WP_000626103.1 NZ_LT905060:c4261750-4261259 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT293669 WP_001110456.1 NZ_LT905060:c4262040-4261747 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References