Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4138874..4139652 Replicon chromosome
Accession NZ_LT905060
Organism Salmonella enterica subsp. enterica serovar Typhi isolate ISP_03_07467_SGB110-sc-1979083

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1C2
Locus tag CJZ88_RS20385 Protein ID WP_000622308.1
Coordinates 4138874..4139362 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1C3
Locus tag CJZ88_RS20390 Protein ID WP_001143724.1
Coordinates 4139359..4139652 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ88_RS20370 4135320..4137605 + 2286 WP_010989300.1 hypothetical protein -
CJZ88_RS20375 4137909..4138160 + 252 WP_024131240.1 hypothetical protein -
CJZ88_RS20380 4138242..4138694 + 453 WP_000434168.1 hypothetical protein -
CJZ88_RS20385 4138874..4139362 - 489 WP_000622308.1 GNAT family N-acetyltransferase Toxin
CJZ88_RS20390 4139359..4139652 - 294 WP_001143724.1 DUF1778 domain-containing protein Antitoxin
CJZ88_RS20395 4140079..4141092 - 1014 WP_000449622.1 site-specific integrase -
CJZ88_RS20400 4141256..4142845 - 1590 WP_000488995.1 TraI domain-containing protein -
CJZ88_RS20405 4142829..4144340 - 1512 WP_001120833.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / tviC / tviD / tviE / vexA / vexB / vexC / vexD / vexE / sopE2 4126658..4259556 132898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.36 Da        Isoelectric Point: 7.3252

>T293668 WP_000622308.1 NZ_LT905060:c4139362-4138874 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10906.59 Da        Isoelectric Point: 6.3493

>AT293668 WP_001143724.1 NZ_LT905060:c4139652-4139359 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A716G941

Antitoxin

Source ID Structure
AlphaFold DB A0A716D9M3

References