Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1395985..1396605 Replicon chromosome
Accession NZ_LT905060
Organism Salmonella enterica subsp. enterica serovar Typhi isolate ISP_03_07467_SGB110-sc-1979083

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag CJZ88_RS06795 Protein ID WP_001280991.1
Coordinates 1395985..1396203 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag CJZ88_RS06800 Protein ID WP_000344807.1
Coordinates 1396231..1396605 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ88_RS06755 1391208..1391777 + 570 WP_000779802.1 YbaY family lipoprotein -
CJZ88_RS06760 1391810..1392199 - 390 WP_000961285.1 MGMT family protein -
CJZ88_RS06770 1392430..1393980 - 1551 WP_000213129.1 EAL domain-containing protein -
CJZ88_RS06775 1394205..1394465 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
CJZ88_RS06780 1394471..1394611 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
CJZ88_RS06785 1394667..1395137 - 471 WP_000136183.1 YlaC family protein -
CJZ88_RS06790 1395255..1395806 - 552 WP_001278793.1 maltose O-acetyltransferase -
CJZ88_RS06795 1395985..1396203 - 219 WP_001280991.1 HHA domain-containing protein Toxin
CJZ88_RS06800 1396231..1396605 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
CJZ88_RS06805 1397101..1400250 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
CJZ88_RS06810 1400273..1401466 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T293661 WP_001280991.1 NZ_LT905060:c1396203-1395985 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT293661 WP_000344807.1 NZ_LT905060:c1396605-1396231 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References