Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1036927..1037577 Replicon chromosome
Accession NC_021082
Organism Mannheimia haemolytica M42548

Toxin (Protein)


Gene name vapC Uniprot ID A0A547EDJ6
Locus tag MHH_RS19125 Protein ID WP_006249411.1
Coordinates 1037188..1037577 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A547EDM1
Locus tag MHH_RS19120 Protein ID WP_006249412.1
Coordinates 1036927..1037187 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHH_RS19105 1032615..1036148 + 3534 WP_006253629.1 transcription-repair coupling factor -
MHH_RS19110 1036311..1036598 + 288 WP_006251764.1 BrnT family toxin -
MHH_RS19115 1036599..1036811 + 213 WP_006251765.1 BrnA antitoxin family protein -
MHH_RS19120 1036927..1037187 + 261 WP_006249412.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MHH_RS19125 1037188..1037577 + 390 WP_006249411.1 type II toxin-antitoxin system VapC family toxin Toxin
MHH_RS19130 1037597..1038835 + 1239 WP_006253630.1 peptidase T -
MHH_RS19150 1039371..1040156 + 786 WP_006251768.1 hypothetical protein -
MHH_RS19155 1040230..1041090 + 861 WP_006250124.1 metal ABC transporter permease -
MHH_RS19160 1041083..1041892 + 810 WP_006250123.1 metal ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14633.91 Da        Isoelectric Point: 7.1041

>T29366 WP_006249411.1 NC_021082:1037188-1037577 [Mannheimia haemolytica M42548]
MYMLDTNTVSYFFRGNANVVAKLKSINPERLCISSVTAAELVYGVAKRNNGQLSQFLDYFLSSVKVLDWNYRCAELYGKL
RAEMEKNGKVMGVQDQMIASHALAEECILVSSDQAFKMVPDLKLENWLH

Download         Length: 390 bp

>T29366 NC_021082:1037188-1037577 [Mannheimia haemolytica M42548]
ATGTATATGTTAGATACGAATACTGTAAGCTATTTTTTTCGTGGAAATGCAAATGTGGTGGCGAAATTGAAGTCCATTAA
TCCTGAGAGGCTTTGTATTTCATCTGTAACTGCTGCTGAATTGGTTTATGGTGTGGCGAAAAGAAATAATGGGCAGCTTT
CTCAATTTTTAGATTATTTTTTATCGAGTGTAAAGGTTTTAGATTGGAATTATCGTTGTGCTGAACTTTATGGAAAGTTA
CGGGCAGAGATGGAGAAAAATGGCAAAGTAATGGGCGTGCAGGATCAAATGATTGCTAGTCACGCTCTTGCTGAAGAGTG
TATTTTAGTTTCTAGTGATCAGGCATTTAAAATGGTACCTGATCTGAAATTGGAGAATTGGTTACACTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10245.54 Da        Isoelectric Point: 4.8951

>AT29366 WP_006249412.1 NC_021082:1036927-1037187 [Mannheimia haemolytica M42548]
MEKIARLFRNGRNQAVRLPVEFEFDAEQVYVSKKENGDILLSLRSRNTEHWQRLFELLPAVVCDETFLDTKERNQSFEQR
DPFEVA

Download         Length: 261 bp

>AT29366 NC_021082:1036927-1037187 [Mannheimia haemolytica M42548]
ATGGAAAAAATTGCGAGATTATTCCGTAACGGGCGGAACCAAGCAGTGCGTTTACCGGTTGAATTTGAGTTTGATGCAGA
GCAAGTCTATGTTTCTAAAAAAGAAAATGGCGATATTTTATTATCATTGAGATCGAGAAATACCGAGCATTGGCAACGAT
TGTTTGAGCTATTGCCTGCTGTTGTATGTGATGAAACATTTTTAGATACAAAAGAGAGAAACCAATCCTTTGAGCAACGG
GATCCTTTTGAGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A547EDJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A547EDM1

References