Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 823756..824381 Replicon chromosome
Accession NZ_LT905060
Organism Salmonella enterica subsp. enterica serovar Typhi isolate ISP_03_07467_SGB110-sc-1979083

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CJZ88_RS04025 Protein ID WP_000911334.1
Coordinates 823983..824381 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag CJZ88_RS04020 Protein ID WP_000557549.1
Coordinates 823756..823983 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ88_RS03990 818927..819646 + 720 WP_000082599.1 Rha family transcriptional regulator -
CJZ88_RS03995 819650..819853 + 204 WP_000184036.1 hypothetical protein -
CJZ88_RS04000 819936..820391 + 456 WP_223229661.1 hypothetical protein -
CJZ88_RS04005 820493..821614 + 1122 WP_000028980.1 hypothetical protein -
CJZ88_RS04010 822247..823053 - 807 WP_077905073.1 DUF1460 domain-containing protein -
CJZ88_RS04015 823328..823579 - 252 WP_001540858.1 hypothetical protein -
CJZ88_RS04020 823756..823983 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
CJZ88_RS04025 823983..824381 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
CJZ88_RS04030 825188..825724 + 537 WP_001038500.1 STM3031 family outer membrane protein -
CJZ88_RS04035 825771..826403 + 633 WP_000835268.1 YfdX family protein -
CJZ88_RS04040 827122..827703 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 816675..843834 27159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T293659 WP_000911334.1 NZ_LT905060:823983-824381 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT293659 WP_000557549.1 NZ_LT905060:823756-823983 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References