Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 205867..206627 Replicon chromosome
Accession NZ_LT905060
Organism Salmonella enterica subsp. enterica serovar Typhi isolate ISP_03_07467_SGB110-sc-1979083

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag CJZ88_RS00975 Protein ID WP_000533908.1
Coordinates 206142..206627 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag CJZ88_RS00970 Protein ID WP_000965889.1
Coordinates 205867..206154 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CJZ88_RS00950 201272..202183 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
CJZ88_RS00955 202193..204262 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
CJZ88_RS00960 204652..205080 + 429 Protein_190 IS3 family transposase -
CJZ88_RS00965 205222..205689 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
CJZ88_RS00970 205867..206154 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
CJZ88_RS00975 206142..206627 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
CJZ88_RS00980 206998..207537 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
CJZ88_RS00985 207713..207925 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
CJZ88_RS00990 208216..208503 - 288 Protein_196 HTH-type transcriptional regulator -
CJZ88_RS00995 208942..209652 + 711 WP_000190524.1 DUF3053 domain-containing protein -
CJZ88_RS01000 209702..210676 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
CJZ88_RS01005 210895..211557 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T293657 WP_000533908.1 NZ_LT905060:206142-206627 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT293657 WP_000965889.1 NZ_LT905060:205867-206154 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References