Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3157917..3159505 Replicon chromosome
Accession NZ_LT903847
Organism Escherichia coli O127:H6 isolate EPEC1

Toxin (Protein)


Gene name hipA Uniprot ID B7URP4
Locus tag BQ9550_RS16605 Protein ID WP_001125430.1
Coordinates 3158183..3159505 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag BQ9550_RS16600 Protein ID WP_001334382.1
Coordinates 3157917..3158183 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9550_RS16580 3154286..3155737 + 1452 WP_000854637.1 tagaturonate reductase -
BQ9550_RS16590 3155934..3156848 + 915 WP_001313828.1 bestrophin family inner membrane protein -
BQ9550_RS16595 3156852..3157610 - 759 WP_001286539.1 trans-aconitate 2-methyltransferase -
BQ9550_RS16600 3157917..3158183 + 267 WP_001334382.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
BQ9550_RS16605 3158183..3159505 + 1323 WP_001125430.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
BQ9550_RS26005 3159613..3159759 + 147 Protein_3055 site-specific integrase -
BQ9550_RS16610 3159751..3160002 + 252 WP_029694049.1 hypothetical protein -
BQ9550_RS16620 3160144..3160527 - 384 Protein_3057 RNA-directed DNA polymerase -
BQ9550_RS16625 3160895..3161197 - 303 WP_000343124.1 hypothetical protein -
BQ9550_RS16630 3161524..3163350 - 1827 WP_012578907.1 AAA family ATPase -
BQ9550_RS16635 3163353..3163838 - 486 WP_001015823.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 3157917..3179908 21991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49297.96 Da        Isoelectric Point: 8.1297

>T293650 WP_001125430.1 NZ_LT903847:3158183-3159505 [Escherichia coli O127:H6]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10017.42 Da        Isoelectric Point: 4.9632

>AT293650 WP_001334382.1 NZ_LT903847:3157917-3158183 [Escherichia coli O127:H6]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4M2E2

Antitoxin

Source ID Structure

References