Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1620669..1621323 Replicon chromosome
Accession NZ_LT903847
Organism Escherichia coli O127:H6 isolate EPEC1

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag BQ9550_RS08390 Protein ID WP_000244781.1
Coordinates 1620916..1621323 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag BQ9550_RS08385 Protein ID WP_000354046.1
Coordinates 1620669..1620935 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9550_RS08365 1616757..1618190 - 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -
BQ9550_RS08370 1618235..1618546 + 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
BQ9550_RS08375 1618710..1619369 + 660 WP_000250274.1 hemolysin III family protein -
BQ9550_RS08380 1619446..1620426 - 981 WP_000886076.1 tRNA-modifying protein YgfZ -
BQ9550_RS08385 1620669..1620935 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
BQ9550_RS08390 1620916..1621323 + 408 WP_000244781.1 protein YgfX Toxin
BQ9550_RS08395 1621363..1621884 - 522 WP_001055874.1 flavodoxin FldB -
BQ9550_RS08400 1621996..1622892 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
BQ9550_RS08405 1622917..1623627 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BQ9550_RS08410 1623633..1625366 + 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T293642 WP_000244781.1 NZ_LT903847:1620916-1621323 [Escherichia coli O127:H6]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT293642 WP_000354046.1 NZ_LT903847:1620669-1620935 [Escherichia coli O127:H6]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References