293641

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1090786..1091417 Replicon chromosome
Accession NZ_LT903847
Organism Escherichia coli O127:H6 isolate EPEC1

Toxin (Protein)


Gene name hicA Uniprot ID L4J012
Locus tag BQ9550_RS05490 Protein ID WP_001260301.1
Coordinates 1090786..1091061 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag BQ9550_RS05495 Protein ID WP_000593555.1
Coordinates 1091058..1091417 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9550_RS05475 1085790..1086857 + 1068 WP_000361455.1 HlyD family secretion protein -
BQ9550_RS05480 1086854..1089589 + 2736 WP_000149096.1 ribosome-associated ATPase/putative transporter RbbA -
BQ9550_RS05485 1089589..1090713 + 1125 WP_001314210.1 ABC transporter permease -
BQ9550_RS05490 1090786..1091061 + 276 WP_001260301.1 type II toxin-antitoxin system HicA family toxin Toxin
BQ9550_RS05495 1091058..1091417 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BQ9550_RS05500 1091537..1091938 - 402 WP_001190063.1 nickel-responsive transcriptional regulator NikR -
BQ9550_RS05505 1091944..1092750 - 807 WP_000173679.1 nickel import ATP-binding protein NikE -
BQ9550_RS05510 1092747..1093511 - 765 WP_001136232.1 nickel import ATP-binding protein NikD -
BQ9550_RS05515 1093511..1094344 - 834 WP_001008954.1 nickel ABC transporter permease subunit NikC -
BQ9550_RS05520 1094341..1095285 - 945 WP_000947070.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.87 Da        Isoelectric Point: 10.6128

>T293641 WP_001260301.1 NZ_LT903847:1090786-1091061 [Escherichia coli O127:H6]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT293641 WP_000593555.1 NZ_LT903847:1091058-1091417 [Escherichia coli O127:H6]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB L4J012

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References