Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 264333..264830 Replicon chromosome
Accession NZ_LT903847
Organism Escherichia coli O127:H6 isolate EPEC1

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag BQ9550_RS01395 Protein ID WP_001173343.1
Coordinates 264333..264506 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag BQ9550_RS01400 Protein ID WP_000398619.1
Coordinates 264534..264830 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9550_RS01385 261003..262460 + 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -
BQ9550_RS01390 262697..264214 + 1518 WP_000003801.1 lysine--tRNA ligase -
BQ9550_RS01395 264333..264506 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
BQ9550_RS01400 264534..264830 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
BQ9550_RS01405 265058..265330 - 273 WP_000405647.1 N-acetyltransferase -
BQ9550_RS01410 265342..265572 - 231 WP_000371707.1 (4Fe-4S)-binding protein -
BQ9550_RS01415 265753..267384 + 1632 WP_001216494.1 sensor histidine kinase -
BQ9550_RS01420 267381..268100 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T293638 WP_001173343.1 NZ_LT903847:c264506-264333 [Escherichia coli O127:H6]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT293638 WP_000398619.1 NZ_LT903847:c264830-264534 [Escherichia coli O127:H6]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References