Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 146..816 Replicon plasmid 4
Accession NZ_LT900341
Organism Gluconobacter oxydans 621H isolate WT-DSMZ

Toxin (Protein)


Gene name vapC Uniprot ID Q5HXJ3
Locus tag BQ9807_RS13985 Protein ID WP_011251566.1
Coordinates 394..816 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A149UQS6
Locus tag BQ9807_RS13980 Protein ID WP_024717005.1
Coordinates 146..397 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BQ9807_RS13980 146..397 + 252 WP_024717005.1 plasmid stabilization protein Antitoxin
BQ9807_RS13985 394..816 + 423 WP_011251566.1 type II toxin-antitoxin system VapC family toxin Toxin
BQ9807_RS13990 816..1471 + 656 Protein_2 hypothetical protein -
BQ9807_RS13995 1695..2090 - 396 WP_080504713.1 helix-turn-helix domain-containing protein -
BQ9807_RS14000 2153..3898 - 1746 WP_080504714.1 Hint domain-containing protein -
BQ9807_RS14005 4101..4697 + 597 WP_080504715.1 recombinase family protein -
BQ9807_RS14010 4818..5414 + 597 WP_024717007.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14547 14547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 18090.56 Da        Isoelectric Point: 12.9461

>T293637 WP_011251566.1 NZ_LT900341:394-816 [Gluconobacter oxydans 621H]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 423 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 10784.64 Da        Isoelectric Point: 12.7191

>AT293637 WP_024717005.1 NZ_LT900341:146-397 [Gluconobacter oxydans 621H]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5HXJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A149UQS6

References