Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1750131..1750756 Replicon chromosome
Accession NZ_LT900021
Organism Thermococcus henrietii strain EXT12c

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CS910_RS09585 Protein ID WP_099211538.1
Coordinates 1750131..1750541 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CS910_RS09590 Protein ID WP_099211540.1
Coordinates 1750526..1750756 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS910_RS09555 1745399..1746394 + 996 WP_099211530.1 AIR synthase family protein -
CS910_RS12080 1746550..1746738 + 189 WP_223211956.1 hypothetical protein -
CS910_RS12185 1746735..1746857 + 123 WP_262926571.1 HEPN domain-containing protein -
CS910_RS09570 1747095..1748168 - 1074 WP_099211532.1 mRNA surveillance protein pelota -
CS910_RS09575 1748209..1748967 - 759 WP_099211534.1 molybdopterin-binding protein -
CS910_RS09580 1749123..1750130 + 1008 WP_099211536.1 phosphorylating glyceraldehyde-3-phosphate dehydrogenase -
CS910_RS09585 1750131..1750541 - 411 WP_099211538.1 PIN domain-containing protein Toxin
CS910_RS09590 1750526..1750756 - 231 WP_099211540.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CS910_RS09595 1750873..1752339 - 1467 Protein_1903 AAA family ATPase -
CS910_RS09600 1752575..1753942 - 1368 WP_099211544.1 ATP-binding protein -
CS910_RS09605 1753968..1754267 - 300 WP_099211546.1 DUF167 domain-containing protein -
CS910_RS09610 1754264..1754767 - 504 WP_099211548.1 DUF402 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(5-48)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15656.88 Da        Isoelectric Point: 4.6409

>T293632 WP_099211538.1 NZ_LT900021:c1750541-1750131 [Thermococcus henrietii]
MHGVIDTNVLIYDTFEDTEFHKKAEETLESLDRWYVPAIVVQEYVWFFKNNGFSAREALEALKGYTEDPRFKGLSEDPRL
IESALDLVVREELSLSRFNDAVILLHALEKGSLVTFDVKLRNLAKRKGVVVLPEEL

Download         Length: 411 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8768.32 Da        Isoelectric Point: 10.5474

>AT293632 WP_099211540.1 NZ_LT900021:c1750756-1750526 [Thermococcus henrietii]
MSITKVTRNYQITIPAEIRKALGIREGELLEVSIEGDRIVLRRLRRERKRLKLGKNVTLGEIEKSIEEGMRECMGS

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References