Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1690485..1691170 Replicon chromosome
Accession NZ_LT900021
Organism Thermococcus henrietii strain EXT12c

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CS910_RS09235 Protein ID WP_099211419.1
Coordinates 1690766..1691170 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CS910_RS09230 Protein ID WP_223211952.1
Coordinates 1690485..1690769 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS910_RS09205 1686415..1688193 + 1779 WP_099211407.1 carbon starvation protein A -
CS910_RS09210 1688233..1688499 + 267 WP_099211409.1 hypothetical protein -
CS910_RS09215 1688509..1689510 + 1002 WP_099211411.1 ArsA family ATPase -
CS910_RS09220 1689491..1689781 + 291 WP_099211413.1 iron-sulfur cluster assembly protein -
CS910_RS09225 1689781..1690437 + 657 WP_099211415.1 hypothetical protein -
CS910_RS09230 1690485..1690769 + 285 WP_223211952.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CS910_RS09235 1690766..1691170 + 405 WP_099211419.1 type II toxin-antitoxin system VapC family toxin Toxin
CS910_RS09240 1691172..1691954 + 783 WP_099211421.1 alpha/beta hydrolase -
CS910_RS09245 1692023..1694077 + 2055 WP_099211423.1 hypothetical protein -
CS910_RS09250 1694070..1695089 - 1020 WP_099211425.1 adenylosuccinate synthetase -
CS910_RS09255 1695248..1695541 + 294 WP_158523833.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15590.06 Da        Isoelectric Point: 4.4500

>T293631 WP_099211419.1 NZ_LT900021:1690766-1691170 [Thermococcus henrietii]
MKLFIDTNLFVYLLTKTPEDERKIIEFYAKLIENHDLYTSPLVLDETIHVAKKKYSVPYELSIEFIDEKVLPYVEVLPLT
VFDYLTARQIIMNYNLRPSDALHVAVIENNGLQAIVSEDEDFDVLPLKRVWLGG

Download         Length: 405 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10601.55 Da        Isoelectric Point: 8.5156

>AT293631 WP_223211952.1 NZ_LT900021:1690485-1690769 [Thermococcus henrietii]
VIPLVSIRLKVGPKGQIVIPKVFREAYGIKEGGEVIVEPTDKGLIIMPKKSKEELIKELLEWKHKRARGKPAKLGELKGI
SLEDEFDEVWGIEE

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References