Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 90638..91245 Replicon chromosome
Accession NZ_LT900021
Organism Thermococcus henrietii strain EXT12c

Toxin (Protein)


Gene name vapC Uniprot ID W8NUN6
Locus tag CS910_RS00515 Protein ID WP_042690980.1
Coordinates 90859..91245 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CS910_RS00510 Protein ID WP_099209227.1
Coordinates 90638..90862 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CS910_RS00500 86067..87476 - 1410 WP_099209225.1 ATP-binding protein -
CS910_RS00505 87537..90548 - 3012 WP_099209226.1 N-6 DNA methylase -
CS910_RS00510 90638..90862 + 225 WP_099209227.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CS910_RS00515 90859..91245 + 387 WP_042690980.1 PIN domain-containing protein Toxin
CS910_RS00520 91242..92657 - 1416 WP_099209228.1 ribonuclease E/G -
CS910_RS00525 92629..93360 - 732 WP_099209229.1 hypothetical protein -
CS910_RS00530 93487..94413 + 927 WP_099209230.1 GTP 3',8-cyclase MoaA -
CS910_RS00535 94457..95404 + 948 WP_099209231.1 DUF835 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-117)

Antitoxin

SpoVT-AbrB domain

(5-45)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14672.16 Da        Isoelectric Point: 9.8982

>T293630 WP_042690980.1 NZ_LT900021:90859-91245 [Thermococcus henrietii]
MTVIDTNVFLYAVLKDSELNEEARNLLASLERWVVPSMVLYELYWFLKKREYSVEDINGVISAVLSSPRTKVVGDNGKYT
KEALKLTKNPKRFNDMVILATAKDFGRLATYDKKLRKEAEKLGIKVLP

Download         Length: 387 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8216.64 Da        Isoelectric Point: 4.5188

>AT293630 WP_099209227.1 NZ_LT900021:90638-90862 [Thermococcus henrietii]
MSLTKVTRNYQITIPSEIRKKLGIKVGDILLVEVEDGKVVLKKSELELPLLPGGKKLTVEEIEETIIEGIGDEE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References