293627

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 518627..519167 Replicon chromosome
Accession NZ_LT897798
Organism Vibrio cholerae isolate Vibrio cholerae str. BC1071

Toxin (Protein)


Gene name relE Uniprot ID A0A151JGK8
Locus tag VCBK1071_RS17150 Protein ID WP_000277238.1
Coordinates 518627..518896 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag VCBK1071_RS17155 Protein ID WP_101411799.1
Coordinates 518889..519167 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCBK1071_RS17115 514051..514764 + 714 WP_000123659.1 Fic family protein -
VCBK1071_RS20670 515070..515241 + 172 Protein_571 DUF645 family protein -
VCBK1071_RS17125 515438..515872 + 435 WP_055030596.1 GNAT family N-acetyltransferase -
VCBK1071_RS17130 516317..516568 + 252 WP_080115527.1 hypothetical protein -
VCBK1071_RS17135 516760..517524 + 765 WP_101411840.1 hypothetical protein -
VCBK1071_RS17145 517660..518484 + 825 WP_084981235.1 hypothetical protein -
VCBK1071_RS17150 518627..518896 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin Toxin
VCBK1071_RS17155 518889..519167 - 279 WP_101411799.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VCBK1071_RS17165 519363..519839 + 477 WP_084981236.1 GNAT family N-acetyltransferase -
VCBK1071_RS17170 519992..520582 + 591 WP_000589659.1 DUF1294 domain-containing protein -
VCBK1071_RS17175 520769..521539 + 771 WP_084981852.1 alpha/beta hydrolase -
VCBK1071_RS17180 522049..522489 + 441 WP_001966102.1 DUF1311 domain-containing protein -
VCBK1071_RS17195 522648..523652 + 1005 WP_101411842.1 LD-carboxypeptidase -
VCBK1071_RS17200 523743..524114 + 372 WP_172440206.1 DUF4144 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 383416..535863 152447
- inside Integron catB9 - 386674..535863 149189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-84)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10406.11 Da        Isoelectric Point: 9.5084

>T293627 WP_000277238.1 NZ_LT897798:c518896-518627 [Vibrio cholerae]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF

Download         Length: 270 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10119.59 Da        Isoelectric Point: 6.0728

>AT293627 WP_101411799.1 NZ_LT897798:c519167-518889 [Vibrio cholerae]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVQQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JGK8

Antitoxin

Source ID Structure

References