293620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 466561..467327 Replicon chromosome
Accession NZ_LT897798
Organism Vibrio cholerae isolate Vibrio cholerae str. BC1071

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag VCBK1071_RS16625 Protein ID WP_000982260.1
Coordinates 466561..467058 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag VCBK1071_RS16630 Protein ID WP_088136754.1
Coordinates 467055..467327 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCBK1071_RS20475 462815..462976 + 162 Protein_488 hypothetical protein -
VCBK1071_RS16595 462994..463254 + 261 WP_032473247.1 DUF3709 domain-containing protein -
VCBK1071_RS16600 463503..463823 + 321 WP_162922770.1 hypothetical protein -
VCBK1071_RS16605 463977..464417 + 441 WP_101411771.1 DUF1311 domain-containing protein -
VCBK1071_RS16615 464577..465329 + 753 Protein_492 SDR family oxidoreductase -
VCBK1071_RS16620 465486..466409 + 924 WP_101411773.1 arginase family protein -
VCBK1071_RS16625 466561..467058 - 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
VCBK1071_RS16630 467055..467327 - 273 WP_088136754.1 DUF1778 domain-containing protein Antitoxin
VCBK1071_RS16640 467582..468877 + 1296 WP_101411777.1 ATP-binding protein -
VCBK1071_RS16645 468882..469784 + 903 WP_101411779.1 DUF4435 domain-containing protein -
VCBK1071_RS16655 469965..470201 - 237 WP_101411782.1 RNA-binding protein -
VCBK1071_RS16665 470520..470924 + 405 WP_080388968.1 hypothetical protein -
VCBK1071_RS16670 471060..471596 + 537 WP_101411786.1 nucleotidyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 383416..535863 152447
- inside Integron catB9 - 386674..535863 149189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T293620 WP_000982260.1 NZ_LT897798:c467058-466561 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9669.19 Da        Isoelectric Point: 6.2988

>AT293620 WP_088136754.1 NZ_LT897798:c467327-467055 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVANAKLKL
AAERYESKTQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure

References