Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 5010224..5010881 Replicon chromosome
Accession NC_021066
Organism Raoultella ornithinolytica B6

Toxin (Protein)


Gene name cptA Uniprot ID A0A808XTM6
Locus tag RORB6_RS23030 Protein ID WP_004867355.1
Coordinates 5010471..5010881 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A514ELX1
Locus tag RORB6_RS23025 Protein ID WP_004867358.1
Coordinates 5010224..5010490 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RORB6_RS23000 5005359..5006792 - 1434 WP_015585781.1 6-phospho-beta-glucosidase -
RORB6_RS23005 5006912..5007640 - 729 WP_015585782.1 MurR/RpiR family transcriptional regulator -
RORB6_RS23010 5007690..5008001 + 312 WP_004867365.1 N(4)-acetylcytidine aminohydrolase -
RORB6_RS23015 5008163..5008822 + 660 WP_004867362.1 hemolysin III family protein -
RORB6_RS23020 5008944..5009927 - 984 WP_015585783.1 tRNA-modifying protein YgfZ -
RORB6_RS23025 5010224..5010490 + 267 WP_004867358.1 FAD assembly factor SdhE Antitoxin
RORB6_RS23030 5010471..5010881 + 411 WP_004867355.1 protein YgfX Toxin
RORB6_RS23035 5010889..5011410 - 522 WP_004867353.1 flavodoxin FldB -
RORB6_RS23040 5011588..5012484 + 897 WP_015585784.1 site-specific tyrosine recombinase XerD -
RORB6_RS23045 5012507..5013220 + 714 WP_004867349.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
RORB6_RS23050 5013226..5014959 + 1734 WP_015585785.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16226.16 Da        Isoelectric Point: 11.3349

>T29362 WP_004867355.1 NC_021066:5010471-5010881 [Raoultella ornithinolytica B6]
VVLWQSDLRISWRSQWFSLLLHGIVAAIVLLMPWPLSYTPLWLLLLSLVVFDSVRSQRRIHACRGEIKLMTDSRLRWQKA
EWEIVGTPWVINSGMLLRLQDMQTRRRQHLWIAADSMDAKEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T29362 NC_021066:5010471-5010881 [Raoultella ornithinolytica B6]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCCTGGCGCTCACAGTGGTTCTCGCTGCTGCTGCACGGCATTGTGGCGGC
TATTGTGCTGCTGATGCCCTGGCCGCTGAGCTACACGCCGCTATGGCTATTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAGATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGTCTGCAGGATATGCAAACGCGTCGCCG
CCAGCATCTGTGGATCGCTGCAGACAGTATGGACGCCAAAGAGTGGCGAGATCTGCGCCGGTTGGTGTTACAAAAACCGG
CACAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10553.05 Da        Isoelectric Point: 4.8432

>AT29362 WP_004867358.1 NC_021066:5010224-5010490 [Raoultella ornithinolytica B6]
MDITNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKQLFIRLLENDDPDLFNWLMNHGEPADAQLQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT29362 NC_021066:5010224-5010490 [Raoultella ornithinolytica B6]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCAGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAACAGCTGTTTATCCGTCTGTTAGAAAACGACGATCCGGATC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCGCAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808XTM6

Antitoxin

Source ID Structure
AlphaFold DB A0A514ELX1

References