293614

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 391606..392165 Replicon chromosome
Accession NZ_LT897798
Organism Vibrio cholerae isolate Vibrio cholerae str. BC1071

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag VCBK1071_RS15875 Protein ID WP_101411655.1
Coordinates 391606..391884 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag VCBK1071_RS15880 Protein ID WP_000381186.1
Coordinates 391881..392165 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCBK1071_RS15835 386674..387636 - 963 WP_101411647.1 integron integrase IntIA -
VCBK1071_RS15840 387896..388123 + 228 WP_101411649.1 hypothetical protein -
VCBK1071_RS15845 388168..388494 + 327 WP_101411651.1 hypothetical protein -
VCBK1071_RS15850 388668..389222 + 555 WP_071187841.1 DUF4875 domain-containing protein -
VCBK1071_RS15855 389526..389708 + 183 WP_000947617.1 DUF645 family protein -
VCBK1071_RS15860 389899..390606 + 708 WP_001893912.1 HAD family hydrolase -
VCBK1071_RS15865 390710..391462 + 753 WP_101411653.1 SDR family oxidoreductase -
VCBK1071_RS15875 391606..391884 - 279 WP_101411655.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VCBK1071_RS15880 391881..392165 - 285 WP_000381186.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
VCBK1071_RS15890 392523..392702 + 180 WP_101411657.1 DUF645 family protein -
VCBK1071_RS15895 392899..393375 + 477 WP_001047184.1 GNAT family N-acetyltransferase -
VCBK1071_RS15905 393520..394278 + 759 WP_033933179.1 hypothetical protein -
VCBK1071_RS15910 394548..395480 + 933 WP_002044844.1 hypothetical protein -
VCBK1071_RS15915 395464..395892 + 429 WP_000082747.1 hypothetical protein -
VCBK1071_RS15920 396073..396519 + 447 WP_084981379.1 hypothetical protein -
VCBK1071_RS15925 396634..397140 + 507 Protein_378 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 383416..535863 152447
- inside Integron catB9 - 386674..535863 149189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10850.55 Da        Isoelectric Point: 4.6794

>T293614 WP_101411655.1 NZ_LT897798:c391884-391606 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10915.28 Da        Isoelectric Point: 8.0775

>AT293614 WP_000381186.1 NZ_LT897798:c392165-391881 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References