Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2169817..2171642 Replicon chromosome
Accession NZ_LT897797
Organism Vibrio cholerae isolate Vibrio cholerae str. BC1071

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag VCBK1071_RS10060 Protein ID WP_172440104.1
Coordinates 2169817..2171178 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag VCBK1071_RS10065 Protein ID WP_000804846.1
Coordinates 2171175..2171642 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VCBK1071_RS10030 2165285..2165731 + 447 WP_000065403.1 DUF2787 domain-containing protein -
VCBK1071_RS10035 2165834..2166820 + 987 WP_002044218.1 GTPase family protein -
VCBK1071_RS10040 2166855..2167496 - 642 WP_032480501.1 inovirus Gp2 family protein -
VCBK1071_RS10045 2167889..2168896 + 1008 WP_101410931.1 CopG family transcriptional regulator -
VCBK1071_RS10050 2168989..2169189 - 201 WP_001293720.1 AlpA family transcriptional regulator -
VCBK1071_RS10060 2169817..2171178 + 1362 WP_172440104.1 type II toxin-antitoxin system HipA family toxin Toxin
VCBK1071_RS10065 2171175..2171642 + 468 WP_000804846.1 helix-turn-helix domain-containing protein Antitoxin
VCBK1071_RS10070 2172066..2172644 + 579 WP_002043479.1 class I SAM-dependent methyltransferase -
VCBK1071_RS10075 2172648..2175584 + 2937 WP_172440105.1 DEAD/DEAH box helicase family protein -
VCBK1071_RS10080 2175654..2176604 + 951 WP_059260525.1 NERD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51235.14 Da        Isoelectric Point: 4.9701

>T293613 WP_172440104.1 NZ_LT897797:2169817-2171178 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIGDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17047.52 Da        Isoelectric Point: 10.7084

>AT293613 WP_000804846.1 NZ_LT897797:2171175-2171642 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References