Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2467122..2468164 Replicon chromosome
Accession NZ_LT883143
Organism Pseudomonas aeruginosa C-NN2 isolate early isolate NN2 (clone C)

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PANN_RS11735 Protein ID WP_003153636.1
Coordinates 2467589..2468164 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PANN_RS11730 Protein ID WP_003050245.1
Coordinates 2467122..2467592 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PANN_RS11695 2462513..2463931 - 1419 WP_004350605.1 TIGR03752 family integrating conjugative element protein -
PANN_RS11700 2463921..2464832 - 912 WP_004350604.1 TIGR03749 family integrating conjugative element protein -
PANN_RS11705 2464829..2465521 - 693 WP_004350603.1 TIGR03746 family integrating conjugative element protein -
PANN_RS11710 2465518..2465916 - 399 WP_003153632.1 TIGR03750 family conjugal transfer protein -
PANN_RS11715 2465929..2466288 - 360 WP_003153634.1 TIGR03745 family integrating conjugative element membrane protein -
PANN_RS11720 2466305..2466538 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
PANN_RS11725 2466535..2466918 - 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PANN_RS11730 2467122..2467592 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PANN_RS11735 2467589..2468164 + 576 WP_003153636.1 PIN domain-containing protein Toxin
PANN_RS11740 2468182..2469096 + 915 WP_003050256.1 AAA family ATPase -
PANN_RS11745 2469093..2469563 + 471 WP_003153638.1 hypothetical protein -
PANN_RS11750 2469560..2470060 + 501 WP_003090159.1 hypothetical protein -
PANN_RS11755 2470060..2470962 + 903 WP_003153640.1 nucleotidyltransferase domain-containing protein -
PANN_RS11760 2471001..2471726 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2412722..2517692 104970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T293608 WP_003153636.1 NZ_LT883143:2467589-2468164 [Pseudomonas aeruginosa C-NN2]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT293608 WP_003050245.1 NZ_LT883143:2467122-2467592 [Pseudomonas aeruginosa C-NN2]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References