Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2417920..2418558 Replicon chromosome
Accession NZ_LT883142
Organism Escherichia coli isolate 6666666.257727.embl

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag EC1094V2_RS14040 Protein ID WP_000813794.1
Coordinates 2418382..2418558 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EC1094V2_RS14035 Protein ID WP_001270286.1
Coordinates 2417920..2418336 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC1094V2_RS14015 2413072..2414013 - 942 WP_032177241.1 ABC transporter permease -
EC1094V2_RS14020 2414014..2415027 - 1014 WP_032177240.1 ABC transporter ATP-binding protein -
EC1094V2_RS14025 2415045..2416190 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
EC1094V2_RS14030 2416435..2417841 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
EC1094V2_RS14035 2417920..2418336 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EC1094V2_RS14040 2418382..2418558 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EC1094V2_RS14045 2418780..2419010 + 231 WP_000494244.1 YncJ family protein -
EC1094V2_RS14050 2419102..2421063 - 1962 WP_001515270.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EC1094V2_RS14055 2421136..2421672 - 537 WP_000429150.1 DNA-binding transcriptional regulator SutR -
EC1094V2_RS14060 2421725..2422939 + 1215 WP_072144128.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T293601 WP_000813794.1 NZ_LT883142:c2418558-2418382 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT293601 WP_001270286.1 NZ_LT883142:c2418336-2417920 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References