Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3435115..3435694 Replicon chromosome
Accession NC_021066
Organism Raoultella ornithinolytica B6

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag RORB6_RS15675 Protein ID WP_015585223.1
Coordinates 3435407..3435694 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag RORB6_RS15670 Protein ID WP_015585222.1
Coordinates 3435115..3435420 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RORB6_RS15650 3430324..3431388 - 1065 WP_004857527.1 DUF2955 domain-containing protein -
RORB6_RS15655 3431378..3432445 - 1068 WP_004857525.1 HlyD family secretion protein -
RORB6_RS15660 3432452..3432916 - 465 WP_004857523.1 MarR family transcriptional regulator -
RORB6_RS25490 3433207..3433371 - 165 WP_004857521.1 DUF1127 domain-containing protein -
RORB6_RS15665 3433548..3434960 + 1413 WP_015585221.1 PLP-dependent aminotransferase family protein -
RORB6_RS15670 3435115..3435420 - 306 WP_015585222.1 BrnA antitoxin family protein Antitoxin
RORB6_RS15675 3435407..3435694 - 288 WP_015585223.1 BrnT family toxin Toxin
RORB6_RS15680 3435811..3436230 - 420 WP_015585224.1 FosA family fosfomycin resistance glutathione transferase -
RORB6_RS15685 3436224..3437132 - 909 WP_015585225.1 LysR family transcriptional regulator -
RORB6_RS15690 3437220..3438002 + 783 WP_015585226.1 NAD(P)H-dependent oxidoreductase -
RORB6_RS15695 3438150..3438728 + 579 WP_004857495.1 TetR/AcrR family transcriptional regulator -
RORB6_RS15700 3438872..3439684 + 813 WP_015585228.1 winged helix-turn-helix domain-containing protein -
RORB6_RS15705 3439681..3440199 + 519 WP_015585229.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11067.49 Da        Isoelectric Point: 7.0747

>T29360 WP_015585223.1 NC_021066:c3435694-3435407 [Raoultella ornithinolytica B6]
MPMEFEWDANKAASNLRKHGIRFEEAVLVFDDPQHLSRQDRYENGEHRWQTIGLVHGIIVILVVHSVRFESGAEVIRIIS
ARKADGKERSRYEHS

Download         Length: 288 bp

>T29360 NC_021066:c3435694-3435407 [Raoultella ornithinolytica B6]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCAGCAAGCAATCTAAGAAAACATGGGATTCGCTTCGAGGAGGCGGT
ACTGGTTTTTGACGATCCGCAGCATCTTTCCCGCCAGGATCGTTATGAAAACGGTGAGCATCGATGGCAAACCATCGGCC
TCGTTCATGGAATTATCGTTATTCTTGTGGTGCATTCGGTCCGCTTTGAAAGCGGGGCTGAGGTGATTCGTATCATCAGC
GCCCGGAAGGCGGACGGCAAAGAGAGGAGTCGTTATGAGCACAGTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11526.01 Da        Isoelectric Point: 9.7545

>AT29360 WP_015585222.1 NC_021066:c3435420-3435115 [Raoultella ornithinolytica B6]
MSTVKYKRDNPAGLSAQREDELRALANKADGEIDYSDIPASGDEQWPDAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIREQNKKS

Download         Length: 306 bp

>AT29360 NC_021066:c3435420-3435115 [Raoultella ornithinolytica B6]
ATGAGCACAGTTAAATACAAGCGCGACAATCCGGCCGGGCTTAGCGCTCAGCGTGAAGACGAGCTCAGAGCGCTGGCGAA
CAAAGCGGATGGCGAAATTGATTACAGCGATATCCCCGCTTCAGGTGATGAACAGTGGCCGGACGCGGTACGCGGTAAAT
TCTACCGACCGTTGAAAACCCAGGCCTCTGTCCGCATCGACGCTGATGTGATGGAGTGGCTTAAACGCCCGGGAAAAGGC
TATCAAACCCGGCTGAACGCGATTTTAAGAGAAGCGATGATTCGCGAGCAGAATAAGAAATCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References