Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2250564..2251090 Replicon chromosome
Accession NZ_LT883142
Organism Escherichia coli isolate 6666666.257727.embl

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag EC1094V2_RS13205 Protein ID WP_000323025.1
Coordinates 2250803..2251090 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag EC1094V2_RS13200 Protein ID WP_000534858.1
Coordinates 2250564..2250803 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC1094V2_RS13165 2245899..2246255 + 357 WP_001310834.1 class I SAM-dependent methyltransferase -
EC1094V2_RS27235 2246866..2247153 + 288 Protein_2102 hypothetical protein -
EC1094V2_RS13180 2247922..2249262 + 1341 WP_000589013.1 ISNCY family transposase -
EC1094V2_RS13190 2249699..2250031 - 333 WP_096321523.1 FlxA-like family protein -
EC1094V2_RS13195 2250234..2250539 - 306 WP_072134164.1 hypothetical protein -
EC1094V2_RS13200 2250564..2250803 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
EC1094V2_RS13205 2250803..2251090 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
EC1094V2_RS13210 2251162..2251317 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
EC1094V2_RS13215 2251534..2251785 + 252 WP_001463433.1 hypothetical protein -
EC1094V2_RS13220 2251852..2252130 + 279 WP_001515373.1 hypothetical protein -
EC1094V2_RS13225 2252132..2253181 + 1050 WP_001515372.1 DUF968 domain-containing protein -
EC1094V2_RS13230 2253199..2253576 + 378 WP_001204787.1 antitermination protein -
EC1094V2_RS13235 2253732..2254256 - 525 WP_000780584.1 lipocalin family protein -
EC1094V2_RS13240 2254449..2255408 + 960 WP_000592549.1 DUF523 and DUF1722 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2237572..2289150 51578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T293599 WP_000323025.1 NZ_LT883142:2250803-2251090 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT293599 WP_000534858.1 NZ_LT883142:2250564-2250803 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References