Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 5980776..5981371 Replicon chromosome
Accession NZ_LT859959
Organism Bradyrhizobium sp. ORS 285

Toxin (Protein)


Gene name hicA Uniprot ID A0A1Y6KPU8
Locus tag BRAD285_RS26865 Protein ID WP_006609255.1
Coordinates 5981183..5981371 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1Y6KMD1
Locus tag BRAD285_RS26860 Protein ID WP_006609254.1
Coordinates 5980776..5981177 (-) Length 134 a.a.

Genomic Context

BRAD285_RS26840BRAD285_RS26850BRAD285_RS26845BRAD285_RS26860BRAD285_RS26865BRAD285_RS26875BRAD285_RS26880BRAD285_RS26885BRAD285_RS26890
Location: 5975818..5978904 (3087 bp)
Type: Others
Protein ID: WP_006609214.1
Location: 5979741..5980259 (519 bp)
Type: Others
Protein ID: WP_006609251.1
Location: 5979263..5979463 (201 bp)
Type: Others
Protein ID: WP_006609250.1
Location: 5980776..5981177 (402 bp)
Type: Antitoxin
Protein ID: WP_006609254.1
Location: 5981183..5981371 (189 bp)
Type: Toxin
Protein ID: WP_006609255.1
Location: 5982324..5983277 (954 bp)
Type: Others
Protein ID: WP_006609256.1
Location: 5983443..5984072 (630 bp)
Type: Others
Protein ID: WP_006609257.1
Location: 5984196..5984963 (768 bp)
Type: Others
Protein ID: WP_172889816.1
Location: 5984963..5986090 (1128 bp)
Type: Others
Protein ID: WP_006609259.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BRAD285_RS268405975818..5978904+3087WP_006609214.1excinuclease ABC subunit UvrB-
BRAD285_RS268455979263..5979463-201WP_006609250.1SEC-C domain-containing protein-
BRAD285_RS268505979741..5980259+519WP_006609251.1transposase-
BRAD285_RS268605980776..5981177-402WP_006609254.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BRAD285_RS268655981183..5981371-189WP_006609255.1type II toxin-antitoxin system HicA family toxinToxin
BRAD285_RS268755982324..5983277-954WP_006609256.1ribose-phosphate pyrophosphokinase-
BRAD285_RS268805983443..5984072-630WP_006609257.1hypothetical protein-
BRAD285_RS268855984196..5984963-768WP_172889816.1peptidoglycan editing factor PgeF-
BRAD285_RS268905984963..5986090-1128WP_006609259.1class I SAM-dependent methyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6955.11 Da        Isoelectric Point: 11.7334

>T293582 WP_006609255.1 NZ_LT859959:c5981371-5981183 [Bradyrhizobium sp. ORS 285]
MNSRDVISVLQRDGWVQIAQKGSHVQFKHPSKKGRVTVPHPSRDLPIGTLKSIEKQAGLKLR

Download         Length: 189 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14365.30 Da        Isoelectric Point: 4.7663

>AT293582 WP_006609254.1 NZ_LT859959:c5981177-5980776 [Bradyrhizobium sp. ORS 285]
MRYYIGLIHKDADSHFGVSFPDLPGVVTAGTTLDDARVMAEEALALHIEGLVEDGEAIPEPSSLEQIMSHRTNRSGVAVL
VPAKVEQSRAVRVNVTLPEDVLAQIDRYAEAHGFTRSGLLVQAAKKLMTDEAA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1Y6KPU8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1Y6KMD1

References