Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 5980776..5981371 Replicon chromosome
Accession NZ_LT859959
Organism Bradyrhizobium sp. ORS 285

Toxin (Protein)


Gene name hicA Uniprot ID A0A1Y6KPU8
Locus tag BRAD285_RS26865 Protein ID WP_006609255.1
Coordinates 5981183..5981371 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1Y6KMD1
Locus tag BRAD285_RS26860 Protein ID WP_006609254.1
Coordinates 5980776..5981177 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BRAD285_RS26840 5975818..5978904 + 3087 WP_006609214.1 excinuclease ABC subunit UvrB -
BRAD285_RS26845 5979263..5979463 - 201 WP_006609250.1 SEC-C domain-containing protein -
BRAD285_RS26850 5979741..5980259 + 519 WP_006609251.1 transposase -
BRAD285_RS26860 5980776..5981177 - 402 WP_006609254.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BRAD285_RS26865 5981183..5981371 - 189 WP_006609255.1 type II toxin-antitoxin system HicA family toxin Toxin
BRAD285_RS26875 5982324..5983277 - 954 WP_006609256.1 ribose-phosphate pyrophosphokinase -
BRAD285_RS26880 5983443..5984072 - 630 WP_006609257.1 hypothetical protein -
BRAD285_RS26885 5984196..5984963 - 768 WP_172889816.1 peptidoglycan editing factor PgeF -
BRAD285_RS26890 5984963..5986090 - 1128 WP_006609259.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6955.11 Da        Isoelectric Point: 11.7334

>T293582 WP_006609255.1 NZ_LT859959:c5981371-5981183 [Bradyrhizobium sp. ORS 285]
MNSRDVISVLQRDGWVQIAQKGSHVQFKHPSKKGRVTVPHPSRDLPIGTLKSIEKQAGLKLR

Download         Length: 189 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14365.30 Da        Isoelectric Point: 4.7663

>AT293582 WP_006609254.1 NZ_LT859959:c5981177-5980776 [Bradyrhizobium sp. ORS 285]
MRYYIGLIHKDADSHFGVSFPDLPGVVTAGTTLDDARVMAEEALALHIEGLVEDGEAIPEPSSLEQIMSHRTNRSGVAVL
VPAKVEQSRAVRVNVTLPEDVLAQIDRYAEAHGFTRSGLLVQAAKKLMTDEAA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6KPU8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y6KMD1

References